A5S is a MyD88 Inhibitor. A5S Alleviates Acute LungInjury with Favorable Drug-like Properties. A5S showed a high MyD88 binding ability and exerted an anti-inflammatory effect through the NF-κB/MAPK pathway. A5S had good stability and safety, showed the highest distribution concentration in the lungs, and exhibited good therapeutic effects on LPS-induced and sepsis-induced ALI mouse models. Most importantly, A5S showed advantages in PK properties, and was identified as a promising MyD88inhibitor with favorable drug-like properties, compared to the only approved MyD88 inhibitor, TJ-M2010-5.
MedKoo Cat#: 128226
Name: A5S
CAS#: N/A
Chemical Formula: C22H26BrN3O2
Exact Mass: 443.1208
Molecular Weight: 444.37
Elemental Analysis: C, 59.46; H, 5.90; Br, 17.98; N, 9.46; O, 7.20
The following data is based on the product molecular weight 444.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
