Synonym
BI02982816; VU6024578; VU-6024578; VU 6024578;
IUPAC/Chemical Name
2-chloro-N-((1,2'-dimethyl-1H,2'H-[3,3'-bipyrazol]-5-yl)methyl)-5-(furan-2-yl)benzamide
InChi Key
DRUXADDGGKWTSU-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H18ClN5O2/c1-25-14(11-17(24-25)18-7-8-23-26(18)2)12-22-20(27)15-10-13(5-6-16(15)21)19-4-3-9-28-19/h3-11H,12H2,1-2H3,(H,22,27)
SMILES Code
CN1C(C2=NN(C)C(CNC(C3=CC(C4=CC=CO4)=CC=C3Cl)=O)=C2)=CC=N1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
395.85
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Reed CW, Kalbfleisch JF, Turkett JA, Trombley TA, Nastase AF, Spearing PK, Haymer DH, Sarwar MM, Quitalig M, Dickerson JW, Blobaum AL, Boutaud O, Voehringer P, Schuelert N, Cho HP, Niswender CM, Rook JM, Priepke H, Ursu D, Conn PJ, Melancon BJ, Lindsley CW. Discovery of VU6024578/BI02982816: An mGlu1 Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition Models. J Med Chem. 2024 Dec 12. doi: 10.1021/acs.jmedchem.4c02554. Epub ahead of print. PMID: 39665415.
