Synonym
Khellol; Chellol;
IUPAC/Chemical Name
7-(hydroxymethyl)-4-methoxy-5H-furo[3,2-g]chromen-5-one
InChi Key
QBZKHNHPZMJJJI-UHFFFAOYSA-N
InChi Code
1S/C13H10O5/c1-16-13-8-2-3-17-10(8)5-11-12(13)9(15)4-7(6-14)18-11/h2-5,14H,6H2,1H3
SMILES Code
COC1=C2C=COC2=CC3=C1C(=O)C=C(CO)O3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
246.22
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Badr JM, Hadad GM, Nahriry K, Hassanean HA. Validated HPLC method for simultaneous estimation of khellol glucoside, khellin and visnagin in Ammi visnaga L. fruits and pharmaceutical preparations. Nat Prod Res. 2015;29(7):593-601. doi: 10.1080/14786419.2014.945170. Epub 2014 Aug 11. PMID: 25111086.
2: CLOETENS W, DE MEY D. Utilisation clinique du khellol-glucoside [Clinical use of khellol-glucoside]. Brux Med. 1954 Aug 15;34(33):1565-74. French. PMID: 13190260.
3: MELON JM. Traitement de l'angor coronarien par le khellol-glucoside [Treatment of angina pectoris with khellol-glucoside]. Brux Med. 1957 Apr 21;37(16):617-22. French. PMID: 13436895.
4: DANN O, ILLING G. Notiz über die Papierchromatographie von Khellin, Visnagin und Khellol-glucosid [Note on Paper chromatography of Khellin, Visnagin and Khellol-glucoside]. Arch Pharm Ber Dtsch Pharm Ges. 1956 Dec;289(12):718-9. German. doi: 10.1002/ardp.19562891209. PMID: 13395462.
5: BARAKAT MZ, BADRAN N. New tests for the identification of khellin, visnagin and khellol-glucoside. J Pharm Pharmacol. 1951 Sep;3(9):576-80. doi: 10.1111/j.2042-7158.1951.tb13102.x. PMID: 14874194.
6: Panneerselvam C, Murugan K, Roni M, Aziz AT, Suresh U, Rajaganesh R, Madhiyazhagan P, Subramaniam J, Dinesh D, Nicoletti M, Higuchi A, Alarfaj AA, Munusamy MA, Kumar S, Desneux N, Benelli G. Fern-synthesized nanoparticles in the fight against malaria: LC/MS analysis of Pteridium aquilinum leaf extract and biosynthesis of silver nanoparticles with high mosquitocidal and antiplasmodial activity. Parasitol Res. 2016 Mar;115(3):997-1013. doi: 10.1007/s00436-015-4828-x. Epub 2015 Nov 27. PMID: 26612497.
7: Stevens TJ, Jones BW, Vidmar TJ, Moran JJ, Manni DS, Day CE. Hypocholesterolemic effect of khellin and khelloside in female cynomolgus monkeys. Arzneimittelforschung. 1985;35(8):1257-60. PMID: 3865654.
8: Schimmer O, Rauch P. Inhibition of metabolic activation of the promutagens, benzo[a]pyrene, 2-aminofluorene and 2-aminoanthracene by furanochromones in Salmonella typhimurium. Mutagenesis. 1998 Jul;13(4):385-9. doi: 10.1093/mutage/13.4.385. PMID: 9717176.
9: Günaydin K, Beyazit N. The chemical investigations on the ripe fruits of Ammi visnaga (Lam.) Lamarck growing in Turkey. Nat Prod Res. 2004 Apr;18(2):169-75. doi: 10.1080/14786410310001608091. PMID: 14984092.
