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MedKoo Cat#: 145651 | Name: Atalantoflavone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Atalantoflavone is also known as trypanocidal compound 2. Atalantoflavone is a promising inhibitor of MDM2-p53 based on its binding affinity.

Chemical Structure

Atalantoflavone
Atalantoflavone
CAS#119309-02-3

Theoretical Analysis

MedKoo Cat#: 145651

Name: Atalantoflavone

CAS#: 119309-02-3

Chemical Formula: C20H16O5

Exact Mass: 336.1000

Molecular Weight: 336.34

Elemental Analysis: C, 71.42; H, 4.80; O, 23.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Atalantoflavone; Limonianin;
IUPAC/Chemical Name
5-hydroxy-2-(4-hydroxyphenyl)-8,8-dimethyl-4H,8H-pyrano[2,3-f]chromen-4-one
InChi Key
YEUHAZULDUVZLA-UHFFFAOYSA-N
InChi Code
1S/C20H16O5/c1-20(2)8-7-13-17(25-20)10-15(23)18-14(22)9-16(24-19(13)18)11-3-5-12(21)6-4-11/h3-10,21,23H,1-2H3
SMILES Code
CC1(C)OC2=C(C=C1)C3=C(C(=O)C=C(O3)C4=CC=C(O)C=C4)C(O)=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 336.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lemos da Silva LA, Höehr de Moraes M, Scotti MT, Scotti L, de Jesus Souza R, Nantchouang Ouete JL, Biavatti MW, Steindel M, Sandjo LP. Antiprotozoal investigation of 20 plant metabolites on Trypanosoma cruzi and Leishmania amazonensis amastigotes. Atalantoflavone alters the mitochondrial membrane potential. Parasitology. 2019 Jun;146(7):849-856. doi: 10.1017/S0031182019000052. Epub 2019 Feb 13. PMID: 30755289. 2: Ndemangou B, Sielinou VT, Vardamides JC, Ali MS, Lateef M, Iqbal L, Afza N, Nkengfack AE. Urease inhibitory isoflavonoids from different parts of Calopogonium mucunoides (Fabaceae). J Enzyme Inhib Med Chem. 2013 Dec;28(6):1156-61. doi: 10.3109/14756366.2012.719025. Epub 2012 Oct 11. PMID: 23057815. 3: Ahmed SA, Kamel EM. Cytotoxic activities of flavonoids from Centaurea scoparia. ScientificWorldJournal. 2014;2014:274207. doi: 10.1155/2014/274207. Epub 2014 Jun 11. PMID: 25114960; PMCID: PMC4075006. 4: Posri P, Suthiwong J, Takomthong P, Wongsa C, Chuenban C, Boonyarat C, Yenjai C. A new flavonoid from the leaves of Atalantia monophylla (L.) DC. Nat Prod Res. 2019 Apr;33(8):1115-1121. doi: 10.1080/14786419.2018.1457667. Epub 2018 Mar 30. PMID: 29600742. 5: Oyedele AK, Adelusi TI, Ogunlana AT, Ayoola MA, Adeyemi RO, Babalola MO, Ayorinde JB, Isong JA, Ajasa TO, Boyenle ID. Promising disruptors of p53-MDM2 dimerization from some medicinal plant phytochemicals: a molecular modeling study. J Biomol Struct Dyn. 2023 Jul-Aug;41(12):5817-5826. doi: 10.1080/07391102.2022.2097313. Epub 2022 Jul 13. PMID: 35822492. 6: Djeussi DE, Sandjo LP, Noumedem JA, Omosa LK, T Ngadjui B, Kuete V. Antibacterial activities of the methanol extracts and compounds from Erythrina sigmoidea against Gram-negative multi-drug resistant phenotypes. BMC Complement Altern Med. 2015 Dec 30;15:453. doi: 10.1186/s12906-015-0978-8. PMID: 26715029; PMCID: PMC4696315. 7: Kuete V, Sandjo LP, Djeussi DE, Zeino M, Kwamou GM, Ngadjui B, Efferth T. Cytotoxic flavonoids and isoflavonoids from Erythrina sigmoidea towards multi- factorial drug resistant cancer cells. Invest New Drugs. 2014 Dec;32(6):1053-62. doi: 10.1007/s10637-014-0137-y. Epub 2014 Jul 19. PMID: 25034000. 8: Ouete JL, Sandjo LP, Kapche DW, Liermann JC, Opatz T, Simo IK, Ngadjui BT. A new flavone from the roots of Milicia excelsa (Moraceae). Z Naturforsch C J Biosci. 2013 Jul-Aug;68(7-8):259-63. PMID: 24066509.

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