MedKoo Cat#: 145635 | Name: Curcolone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Curcolone exhibits inhibition (with inhibition % in the range of 21.28%-67.58%) against collagen-induced platelet aggregation at 100 μM.

Chemical Structure

Curcolone
Curcolone
CAS#17015-43-9

Theoretical Analysis

MedKoo Cat#: 145635

Name: Curcolone

CAS#: 17015-43-9

Chemical Formula: C15H18O3

Exact Mass: 246.1300

Molecular Weight: 246.31

Elemental Analysis: C, 73.15; H, 7.37; O, 19.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Curcolone; Nehipetol;
IUPAC/Chemical Name
(8S,8aS)-8-hydroxy-3,5,8a-trimethyl-7,8,8a,9-tetrahydronaphtho[2,3-b]furan-4(6H)-one
InChi Key
PFIXJSCFTAVWBW-XHDPSFHLSA-N
InChi Code
1S/C15H18O3/c1-8-4-5-11(16)15(3)6-10-12(9(2)7-18-10)14(17)13(8)15/h7,11,16H,4-6H2,1-3H3/t11-,15+/m0/s1
SMILES Code
CC1=COC2=C1C(=O)C3=C(C)CC[C@H](O)[C@@]3(C)C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 246.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hikino H, Sakurai Y, Takemoto T. Structure of curcolone. Chem Pharm Bull (Tokyo). 1967 Jul;15(7):1065-6. PMID: 5583145. 2: Chen JJ, Tsai TH, Liao HR, Chen LC, Kuo YH, Sung PJ, Chen CL, Wei CS. New Sesquiterpenoids and Anti-Platelet Aggregation Constituents from the Rhizomes of Curcuma zedoaria. Molecules. 2016 Oct 17;21(10):1385. doi: 10.3390/molecules21101385. PMID: 27763530; PMCID: PMC6272984. 3: Al-Amin M, Eltayeb NM, Hossain CF, Rahiman SSF, Khairuddean M, Muhamad Salhimi S. Bioactive compounds from Curcuma aeruginosa and the effect of comosone II on the migration and invasion of breast cancer cells. J Asian Nat Prod Res. 2022 Jun 4:1-12. doi: 10.1080/10286020.2022.2081562. Epub ahead of print. PMID: 35658750. 4: Hikino H, Sakurai Y, Takemoto T. Structure and absolute configuration of curcolone. Chem Pharm Bull (Tokyo). 1968 May;16(5):827-31. doi: 10.1248/cpb.16.827. PMID: 5728172.