Synonym
Kuraridine; Kuraridin;
IUPAC/Chemical Name
(R,E)-1-(2,4-dihydroxy-6-methoxy-3-(5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl)phenyl)-3-(2,4-dihydroxyphenyl)prop-2-en-1-one
InChi Key
PIAPWPAWQGDOMN-SXAWMYDMSA-N
InChi Code
1S/C26H30O6/c1-15(2)6-7-18(16(3)4)12-20-23(30)14-24(32-5)25(26(20)31)21(28)11-9-17-8-10-19(27)13-22(17)29/h6,8-11,13-14,18,27,29-31H,3,7,12H2,1-2,4-5H3/b11-9+/t18-/m1/s1
SMILES Code
COC1=C(C(=O)\C=C\C2=C(O)C=C(O)C=C2)C(O)=C(C[C@@H](CC=C(C)C)C(C)=C)C(O)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
438.52
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kim JH, Ryu YB, Kang NS, Lee BW, Heo JS, Jeong IY, Park KH. Glycosidase inhibitory flavonoids from Sophora flavescens. Biol Pharm Bull. 2006 Feb;29(2):302-5. doi: 10.1248/bpb.29.302. PMID: 16462036.
2: Yang X, Baburin I, Plitzko I, Hering S, Hamburger M. HPLC-based activity profiling for GABAA receptor modulators from the traditional Chinese herbal drug Kushen (Sophora flavescens root). Mol Divers. 2011 May;15(2):361-72. doi: 10.1007/s11030-010-9297-7. Epub 2011 Jan 5. PMID: 21207144; PMCID: PMC3196987.
3: Wang F, Shin JY, Kang ES, Kim JH, Jang SI, Cho BO. Kushenol C from Sophora flavescens protects against UVB-induced skin damage in mice through suppression of inflammation and oxidative stress. Heliyon. 2023 Nov 23;9(12):e22804. doi: 10.1016/j.heliyon.2023.e22804. PMID: 38090015; PMCID: PMC10711179.
4: Shin HJ, Kim HJ, Kwak JH, Chun HO, Kim JH, Park H, Kim DH, Lee YS. A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6. doi: 10.1016/s0960-894x(02)00401-8. PMID: 12161123.
5: Zhang L, Xu L, Xiao SS, Liao QF, Li Q, Liang J, Chen XH, Bi KS. Characterization of flavonoids in the extract of Sophora flavescens Ait. by high-performance liquid chromatography coupled with diode-array detector and electrospray ionization mass spectrometry. J Pharm Biomed Anal. 2007 Sep 3;44(5):1019-28. doi: 10.1016/j.jpba.2007.04.019. Epub 2007 Apr 24. PMID: 17658714.
