SHO1122147 is a Mitochondrial Uncoupler for the Treatment of Obesity and Metabolic Dysfunction-Associated Steatohepatitis. SHO1122147 displayed an EC50 of 3.6 μM in L6 myoblasts. Pharmacokinetic studies indicated a half-life of 2 h, Cmax of 35 μM, and no observed adverse effects at 1,000 mg kg−1 dose in mice. In a Gubra-Amylin (GAN) mouse model of MASH, SHO1122147 was efficacious in decreasing body weight and liver triglyceride levels at 200 mg kg−1 day−1 without changes in body temperature
MedKoo Cat#: 128189
Name: SHO1122147
CAS#: N/A
Chemical Formula: C17H11ClN4O2
Exact Mass: 338.0571
Molecular Weight: 338.75
Elemental Analysis: C, 60.28; H, 3.27; Cl, 10.46; N, 16.54; O, 9.45
The following data is based on the product molecular weight 338.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
