ELQ400 | anti- parasite agent

MedKoo Cat#: 128170 | Name: ELQ-400

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ELQ400 is an anti- parasite agent with IC50 = 5 nM.

Chemical Structure

ELQ-400

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128170

Name: ELQ-400

CAS#: N/A

Chemical Formula: C23H14F5NO3

Exact Mass: 447.0894

Molecular Weight: 447.36

Elemental Analysis: C, 61.75; H, 3.15; F, 21.23; N, 3.13; O, 10.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ELQ-400; ELQ400; ELQ 400

IUPAC/Chemical Name

6,7-difluoro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

InChi Key

IPDFJOUPOQYUGZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H14F5NO3/c1-12-21(22(30)17-10-18(24)19(25)11-20(17)29-12)13-2-4-14(5-3-13)31-15-6-8-16(9-7-15)32-23(26,27)28/h2-11H,1H3,(H,29,30)

SMILES Code

CC1=C(C2=CC=C(OC3=CC=C(OC(F)(F)F)C=C3)C=C2)C(C4=CC(F)=C(F)C=C4N1)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 447.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Song Z, Iorga BI, Mounkoro P, Fisher N, Meunier B. The antimalarial compound ELQ-400 is an unusual inhibitor of the bc₁ complex, targeting both Q_o and Q_i sites. FEBS Lett. 2018 Apr;592(8):1346-1356. doi: 10.1002/1873-3468.13035. Epub 2018 Mar 26. PMID: 29574797. 2: Chaudhry S, Zurbriggen R, Preza M, Kämpfer T, Kaethner M, Memedovski R, Scorrano N, Hemphill A, Doggett JS, Lundström-Stadelmann B. Dual inhibition of the Echinococcus multilocularis energy metabolism. Front Vet Sci. 2022 Aug 5;9:981664. doi: 10.3389/fvets.2022.981664. PMID: 35990276; PMCID: PMC9388906. 3: McConnell EV, Bruzual I, Pou S, Winter R, Dodean RA, Smilkstein MJ, Krollenbrock A, Nilsen A, Zakharov LN, Riscoe MK, Doggett JS. Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc₁ and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis. ACS Infect Dis. 2018 Nov 9;4(11):1574-1584. doi: 10.1021/acsinfecdis.8b00133. Epub 2018 Aug 30. PMID: 30117728; PMCID: PMC6884402. 4: Stickles AM, Ting LM, Morrisey JM, Li Y, Mather MW, Meermeier E, Pershing AM, Forquer IP, Miley GP, Pou S, Winter RW, Hinrichs DJ, Kelly JX, Kim K, Vaidya AB, Riscoe MK, Nilsen A. Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy. Am J Trop Med Hyg. 2015 Jun;92(6):1195-201. doi: 10.4269/ajtmh.14-0553. Epub 2015 Apr 27. PMID: 25918204; PMCID: PMC4458825. 5: GC/MS • The ELQ-400 spectrEL® basic. Anal Chem. 1983 Feb 1;55(2):186A. doi: 10.1021/ac00253a755. PMID: 22742265. 6: Rufener R, Dick L, D'Ascoli L, Ritler D, Hizem A, Wells TNC, Hemphill A, Lundström-Stadelmann B. Repurposing of an old drug: In vitro and in vivo efficacies of buparvaquone against Echinococcus multilocularis. Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):440-450. doi: 10.1016/j.ijpddr.2018.10.011. Epub 2018 Oct 31. PMID: 30396011; PMCID: PMC6216040.