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MedKoo Cat#: 128167 | Name: UCB9386

Description:

WARNING: This product is for research use only, not for human or veterinary use.

UCB9386 is a potent, selective, and Brain-Penetrant Nuak1 Inhibitor.

Chemical Structure

UCB9386
UCB9386
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128167

Name: UCB9386

CAS#: N/A

Chemical Formula: C27H28N8O

Exact Mass: 480.2386

Molecular Weight: 480.58

Elemental Analysis: C, 67.48; H, 5.87; N, 23.32; O, 3.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
UCB9386; UCB-9386; UCB 9386
IUPAC/Chemical Name
7-(imidazo[1,2-b]pyridazin-3-yl)-3-(6-methyl-2,6-diazaspiro[3.3]heptan-2-yl)-1-((R)-1-phenylethyl)-4a,8a-dihydropyrido[3,4-b]pyrazin-2(1H)-one
InChi Key
VFJNRLVIPHXWCQ-OSFYOIPJSA-N
InChi Code
InChI=1S/C27H28N8O/c1-18(19-7-4-3-5-8-19)34-22-11-20(23-13-29-24-9-6-10-30-35(23)24)28-12-21(22)31-25(26(34)36)33-16-27(17-33)14-32(2)15-27/h3-13,18,21-22H,14-17H2,1-2H3/t18-,21?,22?/m1/s1
SMILES Code
O=C(C(N1CC2(CN(C)C2)C1)=N3)N([C@@H](C4=CC=CC=C4)C)C(C3C=N5)C=C5C6=CN=C7N6N=CC=C7
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 480.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Poullennec KG, Jnoff E, Abendroth J, Bhuma N, Calmiano M, Calmus L, Cardenas A, Courade JP, Delatour C, Hall A, de Haro T, Delker SL, Demaude T, Gaikwad N, Ghavate D, Gholap AR, Kierkowicz M, Le Mestre R, Van Hijfte N, Verheijden S, Vernerova K, De Wever V, Waghmode N. Discovery of UCB9386: A Potent, Selective, and Brain-Penetrant Nuak1 Inhibitor Suitable for In Vivo Pharmacological Studies. J Med Chem. 2024 Nov 26. doi: 10.1021/acs.jmedchem.4c01237. Epub ahead of print. PMID: 39588908.