MedKoo Cat#: 145596 | Name: Norartocarpetin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Norartocarpetin is one of the antioxidant and antityrosinase activity compound in Artocarpus communis. Norartocarpetin could be used as a whitening agent in medicine

Chemical Structure

Norartocarpetin
Norartocarpetin
CAS#520-30-9

Theoretical Analysis

MedKoo Cat#: 145596

Name: Norartocarpetin

CAS#: 520-30-9

Chemical Formula: C15H10O6

Exact Mass: 286.0500

Molecular Weight: 286.24

Elemental Analysis: C, 62.94; H, 3.52; O, 33.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Norartocarpetin;
IUPAC/Chemical Name
2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
InChi Key
ZSYPIPFQOQGYHH-UHFFFAOYSA-N
InChi Code
1S/C15H10O6/c16-7-1-2-9(10(18)3-7)13-6-12(20)15-11(19)4-8(17)5-14(15)21-13/h1-6,16-19H
SMILES Code
OC1=CC(O)=C(C=C1)C2=CC(=O)C3=C(O)C=C(O)C=C3O2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 286.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ko HH, Tsai YT, Yen MH, Lin CC, Liang CJ, Yang TH, Lee CW, Yen FL. Norartocarpetin from a folk medicine Artocarpus communis plays a melanogenesis inhibitor without cytotoxicity in B16F10 cell and skin irritation in mice. BMC Complement Altern Med. 2013 Dec 10;13:348. doi: 10.1186/1472-6882-13-348. PMID: 24325567; PMCID: PMC3878891. 2: Guo N, Xiao Y, Chen D, Wang J. Antiproliferative effects of Norartocarpetin isoflavone in human lung carcinoma cells are mediated via targeting Ras/Raf/MAPK signalling pathway, mitochondrial mediated apoptosis, S-phase cell cycle arrest and suppression of cell migration and invasion. J BUON. 2020 Mar- Apr;25(2):855-861. PMID: 32521878. 3: Zheng ZP, Dong X, Yuan K, Lan S, Zhu Q, Wang M, Chen J. Preparation, characterization, and preliminary antibrowning evaluations of norartocarpetin microemulsions. J Agric Food Chem. 2015 Feb 11;63(5):1615-21. doi: 10.1021/jf5048805. Epub 2015 Jan 29. PMID: 25603116. 4: Zheng ZP, Yan Y, Xia J, Zhang S, Wang M, Chen J, Xu Y. A phenylacetaldehyde- flavonoid adduct, 8-C-(E-phenylethenyl)-norartocarpetin, exhibits intrinsic apoptosis and MAPK pathways-related anticancer potential on HepG2, SMMC-7721 and QGY-7703. Food Chem. 2016 Apr 15;197 Pt B:1085-92. doi: 10.1016/j.foodchem.2015.11.104. Epub 2015 Nov 27. PMID: 26675844. 5: Zhang L, Zhao X, Tao GJ, Chen J, Zheng ZP. Investigating the inhibitory activity and mechanism differences between norartocarpetin and luteolin for tyrosinase: A combinatory kinetic study and computational simulation analysis. Food Chem. 2017 May 15;223:40-48. doi: 10.1016/j.foodchem.2016.12.017. Epub 2016 Dec 9. PMID: 28069121. 6: Belmonte-Herrera BH, Domínguez-Avila JA, Wall-Medrano A, Ayala-Zavala JF, Preciado-Saldaña AM, Salazar-López NJ, López-Martínez LX, Yahia EM, Robles- Sánchez RM, González-Aguilar GA. Lesser-Consumed Tropical Fruits and Their by- Products: Phytochemical Content and Their Antioxidant and Anti-Inflammatory Potential. Nutrients. 2022 Sep 5;14(17):3663. doi: 10.3390/nu14173663. PMID: 36079920; PMCID: PMC9460136. 7: Ryu YB, Ha TJ, Curtis-Long MJ, Ryu HW, Gal SW, Park KH. Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz. J Enzyme Inhib Med Chem. 2008 Dec;23(6):922-30. doi: 10.1080/14756360701810207. PMID: 18608767. 8: Monteiro AFM, Viana JO, Nayarisseri A, Zondegoumba EN, Mendonça Junior FJB, Scotti MT, Scotti L. Computational Studies Applied to Flavonoids against Alzheimer's and Parkinson's Diseases. Oxid Med Cell Longev. 2018 Dec 30;2018:7912765. doi: 10.1155/2018/7912765. PMID: 30693065; PMCID: PMC6332933. 9: Likhitwitayawuid K, Sritularak B, De-Eknamkul W. Tyrosinase inhibitors from Artocarpus gomezianus. Planta Med. 2000 Apr;66(3):275-7. doi: 10.1055/s-2000-8656. PMID: 10821057. 10: Ouassou H, Elhouda Daoudi N, Bouknana S, Abdnim R, Bnouham M. A Review of Antidiabetic Medicinal Plants as a Novel Source of Phosphodiesterase Inhibitors: Future Perspective of New Challenges Against Diabetes Mellitus. Med Chem. 2024;20(5):467-486. doi: 10.2174/0115734064255060231116192839. PMID: 38265379. 11: Bai X, Zhao X, Liu K, Yang X, He Q, Gao Y, Li W, Han W. Mulberry Leaf Compounds and Gut Microbiota in Alzheimer's Disease and Diabetes: A Study Using Network Pharmacology, Molecular Dynamics Simulation, and Cellular Assays. Int J Mol Sci. 2024 Apr 5;25(7):4062. doi: 10.3390/ijms25074062. PMID: 38612872; PMCID: PMC11012793. 12: Yang T, Yang Z, Pan F, Jia Y, Cai S, Zhao L, Zhao L, Wang O, Wang C. Construction of an MLR-QSAR Model Based on Dietary Flavonoids and Screening of Natural α-Glucosidase Inhibitors. Foods. 2022 Dec 14;11(24):4046. doi: 10.3390/foods11244046. PMID: 36553788; PMCID: PMC9778400. 13: Nguyen HX, Nguyen NT, Nguyen MH, Le TH, Van Do TN, Hung TM, Nguyen MT. Tyrosinase inhibitory activity of flavonoids from Artocarpus heterophyllous. Chem Cent J. 2016 Jan 29;10:2. doi: 10.1186/s13065-016-0150-7. PMID: 26834825; PMCID: PMC4734850. 14: Ti H, Wu P, Lin L, Wei X. Stilbenes and flavonoids from Artocarpus nitidus subsp. lingnanensis. Fitoterapia. 2011 Jun;82(4):662-5. doi: 10.1016/j.fitote.2011.02.001. Epub 2011 Feb 18. PMID: 21316425. 15: Jin YJ, Lin CC, Lu TM, Li JH, Chen IS, Kuo YH, Ko HH. Chemical constituents derived from Artocarpus xanthocarpus as inhibitors of melanin biosynthesis. Phytochemistry. 2015 Sep;117:424-435. doi: 10.1016/j.phytochem.2015.07.003. Epub 2015 Jul 15. PMID: 26188915. 16: Zheng Y, Yang XW, Schols D, Mori M, Botta B, Chevigné A, Mulinge M, Steinmetz A, Schmit JC, Seguin-Devaux C. Active Components from Cassia abbreviata Prevent HIV-1 Entry by Distinct Mechanisms of Action. Int J Mol Sci. 2021 May 10;22(9):5052. doi: 10.3390/ijms22095052. PMID: 34068829; PMCID: PMC8126241. 17: Wang L, Yang Y, Liu C, Chen RY. Three new compounds from Morus nigra L. J Asian Nat Prod Res. 2010 Jun;12(6):431-7. doi: 10.1080/10286020.2010.489824. PMID: 20552479. 18: Su BN, Cuendet M, Hawthorne ME, Kardono LB, Riswan S, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD. Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity. J Nat Prod. 2002 Feb;65(2):163-9. doi: 10.1021/np010451c. PMID: 11858749. 19: Likhitwitayawuid K, Chaiwiriya S, Sritularak B, Lipipun V. Antiherpetic flavones from the heartwood of Artocarpus gomezianus. Chem Biodivers. 2006 Oct;3(10):1138-43. doi: 10.1002/cbdv.200690115. PMID: 17193228. 20: Arung ET, Shimizu K, Kondo R. Artocarpus plants as a potential source of skin whitening agents. Nat Prod Commun. 2011 Sep;6(9):1397-402. PMID: 21941923.