IUPAC/Chemical Name
2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane
InChi Key
DPYMFVXJLLWWEU-UHFFFAOYSA-N
InChi Code
1S/C3H2F6O/c4-1(3(7,8)9)10-2(5)6/h1-2H
SMILES Code
FC(F)OC(F)C(F)(F)F
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
168.04
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hendrickx JFA, Nielsen OJ, De Hert S, De Wolf AM. The science behind banning desflurane: A narrative review. Eur J Anaesthesiol. 2022 Oct 1;39(10):818-824. doi: 10.1097/EJA.0000000000001739. Epub 2022 Aug 29. PMID: 36036420.
2: Answine JF. Desflurane Should Not Des-appear. Anesth Analg. 2021 Mar 1;132(3):e41-e42. doi: 10.1213/ANE.0000000000005319. PMID: 33591099.
3: Qin H, Zhou J. Myocardial Protection by Desflurane: From Basic Mechanisms to Clinical Applications. J Cardiovasc Pharmacol. 2023 Sep 1;82(3):169-179. doi: 10.1097/FJC.0000000000001448. PMID: 37405905.
4: Moonesinghe SR. Desflurane decommissioning: more than meets the eye. Anaesthesia. 2024 Mar;79(3):237-241. doi: 10.1111/anae.16219. Epub 2024 Jan 11. PMID: 38207006.
5: Shelton CL, Sutton R, White SM. Desflurane in modern anaesthetic practice: walking on thin ice(caps)? Br J Anaesth. 2020 Dec;125(6):852-856. doi: 10.1016/j.bja.2020.09.013. Epub 2020 Oct 7. PMID: 33039121.
6: Lee S. Can desflurane be an alternative to sevoflurane in neuroanesthesia? Korean J Anesthesiol. 2019 Jun;72(3):207-208. doi: 10.4097/kja.19199. Epub 2019 May 31. PMID: 31161758; PMCID: PMC6547238.
7: Lobaz S, Randles D, Thomas D. Desflurane vaporiser contamination. Anaesthesia. 2014 Feb;69(2):190-1. doi: 10.1111/anae.12566. PMID: 24443867.
8: Wang C, Li L, Xu H, Lv H, Zhang H. Effect of desflurane-remifentanil or sevoflurane-remifentanil on early recovery in elderly patients: a meta-analysis of randomized controlled trials. Pharmazie. 2019 Apr 1;74(4):201-205. doi: 10.1691/ph.2019.8935. PMID: 30940302.
9: Sneyd JR. Thiopental to desflurane - an anaesthetic journey. Where are we going next? Br J Anaesth. 2017 Dec 1;119(suppl_1):i44-i52. doi: 10.1093/bja/aex328. PMID: 29161390.
10: Zhong M, Che L, Du M, Liu K, Wang D. Desflurane protects against liver ischemia/reperfusion injury via regulating miR-135b-5p. J Chin Med Assoc. 2021 Jan 1;84(1):38-45. doi: 10.1097/JCMA.0000000000000427. PMID: 32898087.
11: Kmietowicz Z. Desflurane: Use of carbon emitting anaesthetic to end in England. BMJ. 2023 Jan 13;380:102. doi: 10.1136/bmj.p102. PMID: 36639151.
12: Cleland J, Bill V, Williams E, Shelton C. Retained desflurane in decommissioned vaporisers: a national problem? Anaesthesia. 2023 May;78(5):651-652. doi: 10.1111/anae.15930. Epub 2022 Nov 28. PMID: 36437774.
13: Meyer MJ. Desflurane Should Des-appear: Global and Financial Rationale. Anesth Analg. 2020 Oct;131(4):1317-1322. doi: 10.1213/ANE.0000000000005102. PMID: 32925355.
14: Silverman J. How to resolve a dilemma about desflurane? Lab Anim (NY). 2020 Mar;49(3):55. doi: 10.1038/s41684-020-0482-8. PMID: 32099136.
15: Frink EJ Jr. Desflurane--a new inhalation anesthetic. West J Med. 1995 Jan;162(1):54. PMID: 7863661; PMCID: PMC1022597.
16: Baronos S, Selvaraj BJ, Liang M, Ahmed K, Yarmush J. Sugammadex-induced bronchospasm during desflurane anaesthesia. Br J Anaesth. 2019 Jul;123(1):e155-e156. doi: 10.1016/j.bja.2019.04.001. Epub 2019 Apr 24. PMID: 31027913.
17: Dexter F, Hindman BJ. Systematic review with meta-analysis of relative risk of prolonged times to tracheal extubation with desflurane versus sevoflurane or isoflurane. J Clin Anesth. 2023 Nov;90:111210. doi: 10.1016/j.jclinane.2023.111210. Epub 2023 Jul 21. PMID: 37481911.
18: White PF. Studies of desflurane in outpatient anesthesia. Anesth Analg. 1992 Oct;75(4 Suppl):S47-53; discussion S53-4. PMID: 1524240.
19: Chen YC, Chen SY, Chen TY, Pan JI, Tsai ST. Desflurane and sevoflurane differentially affect activity of the subthalamic nucleus in Parkinson's disease. Br J Anaesth. 2021 Feb;126(2):477-485. doi: 10.1016/j.bja.2020.09.041. Epub 2020 Nov 5. PMID: 33160604.
20: Hudetz AG, Pillay S, Wang S, Lee H. Desflurane Anesthesia Alters Cortical Layer-specific Hierarchical Interactions in Rat Cerebral Cortex. Anesthesiology. 2020 May;132(5):1080-1090. doi: 10.1097/ALN.0000000000003179. PMID: 32101967; PMCID: PMC8190972.