SUN-C8257 | chymase inhibitor

MedKoo Cat#: 128139 | Name: SUN-C8257

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SUN-C8257 is a chymase inhibitor.

Chemical Structure

SUN-C8257

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128139

Name: SUN-C8257

CAS#: N/A

Chemical Formula: C15H10ClN3O6S

Exact Mass: 394.9979

Molecular Weight: 395.77

Elemental Analysis: C, 45.52; H, 2.55; Cl, 8.96; N, 10.62; O, 24.25; S, 8.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SUN-C8257; SUNC8257; SUN C8257

IUPAC/Chemical Name

2-amino-4-((7-chloro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)sulfonyl)benzoic acid

InChi Key

MVSVIOVDISKPIS-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H10ClN3O6S/c16-7-1-3-10-12(5-7)18-15(23)19(13(10)20)26(24,25)8-2-4-9(14(21)22)11(17)6-8/h1-6H,17H2,(H,18,23)(H,21,22)

SMILES Code

ClC1=CC2=C(C(N(S(C3=CC=C(C(O)=O)C(N)=C3)(=O)=O)C(N2)=O)=O)C=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 395.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Doggrell SA, Wanstall JC. Vascular chymase: pathophysiological role and therapeutic potential of inhibition. Cardiovasc Res. 2004 Mar 1;61(4):653-62. doi: 10.1016/j.cardiores.2003.11.029. PMID: 14985062. 2: Watanabe N, Miura K, Fukuda Y. Chymase inhibitor ameliorates eosinophilia in mice infected with Nippostrongylus brasiliensis. Int Arch Allergy Immunol. 2002 Jul;128(3):235-9. doi: 10.1159/000064257. PMID: 12119506. 3: Uehara Y, Urata H, Ideishi M, Arakawa K, Saku K. Chymase inhibition suppresses high-cholesterol diet-induced lipid accumulation in the hamster aorta. Cardiovasc Res. 2002 Sep;55(4):870-6. doi: 10.1016/s0008-6363(02)00458-3. PMID: 12176136. 4: Doggrell SA, Wanstall JC. Cardiac chymase: pathophysiological role and therapeutic potential of chymase inhibitors. Can J Physiol Pharmacol. 2005 Feb;83(2):123-30. doi: 10.1139/y04-136. PMID: 15791285. 5: Watanabe N, Tomimori Y, Saito K, Miura K, Wada A, Tsudzuki M, Fukuda Y. Chymase inhibitor improves dermatitis in NC/Nga mice. Int Arch Allergy Immunol. 2002 Jul;128(3):229-34. doi: 10.1159/000064256. PMID: 12119505.