Ac-IEPD-AFC | fluorogenic substrate for granzyme B | CAS#1135417-31-0

MedKoo Cat#: 128134 | Name: Ac-IEPD-AFC

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ac-IEPD-AFC is a fluorogenic substrate for granzyme B. Upon enzymatic cleavage by granzyme B, 7-amino-4-trifluoromethylcoumarin (AFC) is released and its fluorescence can be used to quantify granzyme B activity.

Chemical Structure

Ac-IEPD-AFC

CAS#1135417-31-0

Theoretical Analysis

MedKoo Cat#: 128134

Name: Ac-IEPD-AFC

CAS#: 1135417-31-0

Chemical Formula: C32H38F3N5O11

Exact Mass: 725.2520

Molecular Weight: 725.68

Elemental Analysis: C, 52.96; H, 5.28; F, 7.85; N, 9.65; O, 24.25

Price and Availability

Size	Price	Availability
1mg	USD 350.00	2 Weeks
5mg	USD 650.00	2 Weeks
10mg	USD 950.00	2 Weeks

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Related CAS #

No Data

Synonym

Ac-IEPD-AFC; Ac-Ile-Glu-Pro-Asp-AFC

IUPAC/Chemical Name

(S)-4-((2S,3S)-2-acetamido-3-methylpentanamido)-5-((S)-2-(((S)-3-carboxy-1-oxo-1-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl)amino)propan-2-yl)carbamoyl)pyrrolidin-1-yl)-5-oxopentanoic acid

InChi Key

HWXKKVLJPWMVLL-FGGUPADCSA-N

InChi Code

InChI=1S/C32H38F3N5O11/c1-4-15(2)27(36-16(3)41)30(49)38-20(9-10-24(42)43)31(50)40-11-5-6-22(40)29(48)39-21(14-25(44)45)28(47)37-17-7-8-18-19(32(33,34)35)13-26(46)51-23(18)12-17/h7-8,12-13,15,20-22,27H,4-6,9-11,14H2,1-3H3,(H,36,41)(H,37,47)(H,38,49)(H,39,48)(H,42,43)(H,44,45)/t15-,20-,21-,22-,27-/m0/s1

SMILES Code

O=C([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)[C@H](CC)C)=O)N1CCC[C@H]1C(N[C@H](C(NC2=CC=C3C(OC(C=C3C(F)(F)F)=O)=C2)=O)CC(O)=O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 725.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.