SD-436 is a highly potent and selective STAT3 degrader. A single intravenous administration of SD-436 at 5 mg/kg effectively induces rapid, complete, and durable depletion of STAT3 in mouse native and xenograft tumor tissues. SD-436 achieves complete and long-lasting tumor regression even with a weekly dosing schedule in leukemia and lymphoma xenograft models in mice.
MedKoo Cat#: 128122
Name: SD-436
CAS#: N/A
Chemical Formula: C58H62F4N9O14PS
Exact Mass: 1247.3811
Molecular Weight: 1248.21
Elemental Analysis: C, 55.81; H, 5.01; F, 6.09; N, 10.10; O, 17.94; P, 2.48; S, 2.57
The following data is based on the product molecular weight 1,248.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
