MedKoo Cat#: 128119 | Name: UNC-CA2-103
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

UNC-CA2-103 is an inhibitor of tousled-like kinase 2 (TLK2; IC50 = 18 nM).

Chemical Structure

UNC-CA2-103
UNC-CA2-103
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128119

Name: UNC-CA2-103

CAS#: N/A

Chemical Formula: C20H16N4O2

Exact Mass: 344.1273

Molecular Weight: 344.37

Elemental Analysis: C, 69.76; H, 4.68; N, 16.27; O, 9.29

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
5mg USD 650.00 2 Weeks
10mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
UNC-CA2-103; UNC-CA2 103; UNC CA2-103; UNC CA2 103
IUPAC/Chemical Name
(Z)-N-(3-((4-methyl-1H-imidazol-5-yl)methylene)-2-oxoindolin-5-yl)benzamide
InChi Key
FDJSILGLKCJVAQ-YBEGLDIGSA-N
InChi Code
InChI=1S/C20H16N4O2/c1-12-18(22-11-21-12)10-16-15-9-14(7-8-17(15)24-20(16)26)23-19(25)13-5-3-2-4-6-13/h2-11H,1H3,(H,21,22)(H,23,25)(H,24,26)/b16-10-
SMILES Code
O=C1NC2=CC=C(NC(C3=CC=CC=C3)=O)C=C2/C1=C/C4=C(C)N=CN4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 344.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Asquith CRM, East MP, Laitinen T, Alamillo-Ferrer C, Hartikainen E, Wells CI, Axtman AD, Drewry DH, Tizzard GJ, Poso A, Willson TM, Johnson GL. Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships. Eur J Med Chem. 2024 May 5;271:116357. doi: 10.1016/j.ejmech.2024.116357. Epub 2024 Apr 2. PMID: 38636130; PMCID: PMC11421834.