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MedKoo Cat#: 128108 | Name: Atractylon
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Atractylon is a sesquiterpene that has been found in A. lancea and has diverse biological activities. It scavenges DPPH radicals in a cell-free assay when used at concentrations of 0.01, 0.1, or 1 mg/ml.

Chemical Structure

Atractylon
Atractylon
CAS#6989-21-5

Theoretical Analysis

MedKoo Cat#: 128108

Name: Atractylon

CAS#: 6989-21-5

Chemical Formula: C15H20O

Exact Mass: 216.1514

Molecular Weight: 216.32

Elemental Analysis: C, 83.28; H, 9.32; O, 7.40

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 550.00 2 Weeks
25mg USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
Atractylon; Atractylone; Atractyloxide
IUPAC/Chemical Name
(4aS,8aR)-3,8a-dimethyl-5-methylene-4,4a,5,6,7,8,8a,9-octahydronaphtho[2,3-b]furan
InChi Key
TYPSVDGIQAOBAD-DZGCQCFKSA-N
InChi Code
InChI=1S/C15H20O/c1-10-5-4-6-15(3)8-14-12(7-13(10)15)11(2)9-16-14/h9,13H,1,4-8H2,2-3H3/t13-,15+/m0/s1
SMILES Code
C[C@]12[C@@](C(CCC2)=C)([H])CC3=C(OC=C3C)C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 216.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sun S, Shi J, Wang X, Huang C, Huang Y, Xu J, Jiang Y, Cao L, Xie T, Wang Y, Huang Z. Atractylon inhibits the tumorigenesis of glioblastoma through SIRT3 signaling. Am J Cancer Res. 2022 May 15;12(5):2310-2322. PMID: 35693089; PMCID: PMC9185613. 2: Li H, Wang F, Zhou Z, Jiang X, Li F, Feng Y, Liu C, Zhang Y, Fan S, Wu X, Huang C. Atractylon, a novel dopamine 2 receptor agonist, ameliorates Parkinsonian like motor dysfunctions in MPTP-induced mice. Neurotoxicology. 2022 Mar;89:121-126. doi: 10.1016/j.neuro.2022.01.010. Epub 2022 Jan 31. PMID: 35104500. 3: Cheng Y, Mai JY, Hou TL, Ping J, Chen JJ. Antiviral activities of atractylon from Atractylodis Rhizoma. Mol Med Rep. 2016 Oct;14(4):3704-10. doi: 10.3892/mmr.2016.5713. Epub 2016 Sep 5. PMID: 27600871; PMCID: PMC5042776. 4: Cheng Y, Chen T, Yang X, Xue J, Chen J. Atractylon induces apoptosis and suppresses metastasis in hepatic cancer cells and inhibits growth in vivo. Cancer Manag Res. 2019 Jun 28;11:5883-5894. doi: 10.2147/CMAR.S194795. PMID: 31388314; PMCID: PMC6607983. 5: Mao J, Wang X, Yu M, Sun C. Effects of Atractylon on Proliferation and Apoptosis of Intestinal Cancer Cells Through PI3K/AKT/mTOR Signaling Pathway. Cell Mol Biol (Noisy-le-grand). 2022 May 31;68(5):153-160. doi: 10.14715/cmb/2022.68.5.21. PMID: 36029491. 6: Yun C, Zhao Z, Gu L, Zhang Z, Wang S, Shi Y, Miao N, Ri I, Wang W, Wang H. In vitro production of atractylon and β-eudesmol from Atractylodes chinensis by adventitious root culture. Appl Microbiol Biotechnol. 2022 Nov;106(21):7027-7037. doi: 10.1007/s00253-022-12194-5. Epub 2022 Sep 29. PMID: 36171502. 7: Cheng Y, Ping J, Chen J, Fu Y, Zhao H, Xue J. Molecular mechanism of atractylon in the invasion and migration of hepatic cancer cells based on high‑throughput sequencing. Mol Med Rep. 2022 Apr;25(4):112. doi: 10.3892/mmr.2022.12628. Epub 2022 Feb 4. Retraction in: Mol Med Rep. 2025 Jan;31(1):8. doi: 10.3892/mmr.2024.13373. PMID: 35119084; PMCID: PMC8845028. 8: Hwang JM, Tseng TH, Hsieh YS, Chou FP, Wang CJ, Chu CY. Inhibitory effect of atractylon on tert-butyl hydroperoxide induced DNA damage and hepatic toxicity in rat hepatocytes. Arch Toxicol. 1996;70(10):640-4. doi: 10.1007/s002040050323. PMID: 8870957. 9: Lin Y, Liu X, Tan D, Jiang Z. Atractylon treatment prevents sleep-disordered breathing-induced cognitive dysfunction by suppression of chronic intermittent hypoxia-induced M1 microglial activation. Biosci Rep. 2020 Jun 26;40(6):BSR20192800. doi: 10.1042/BSR20192800. PMID: 32490526; PMCID: PMC7295624. 10: Yan H, Sun Y, Ma Y, Ji B, Hou X, Yu Z, Zhao Y. Determination of atractylon in rat plasma by a GC-MS method and its application to a pharmacokinetic study. J Pharm Anal. 2015 Oct;5(5):327-331. doi: 10.1016/j.jpha.2015.03.002. Epub 2015 Mar 28. PMID: 29403946; PMCID: PMC5762239. 11: Kim HK, Yun YK, Ahn YJ. Toxicity of atractylon and atractylenolide III Identified in Atractylodes ovata rhizome to Dermatophagoides farinae and Dermatophagoides pteronyssinus. J Agric Food Chem. 2007 Jul 25;55(15):6027-31. doi: 10.1021/jf0708802. Epub 2007 Jun 27. PMID: 17595110. 12: Zeng H, Gao H, Zhang M, Wang J, Gu Y, Wang Y, Zhang H, Liu P, Zhang X, Zhao L. Atractylon Treatment Attenuates Pulmonary Fibrosis via Regulation of the mmu_circ_0000981/miR-211-5p/TGFBR2 Axis in an Ovalbumin-Induced Asthma Mouse Model. Inflammation. 2021 Oct;44(5):1856-1864. doi: 10.1007/s10753-021-01463-6. Epub 2021 Apr 14. PMID: 33855682. 13: Expression of Concern: Atractylon treatment prevents sleep-disordered breathing-induced cognitive dysfunction by suppression of chronic intermittent hypoxia-induced M1 microglial activation. Biosci Rep. 2023 May 31;43(5):BSR-2019-2800_EOC. doi: 10.1042/BSR-2019-2800_EOC. PMID: 37218500; PMCID: PMC10214095. 14: Zhai C, Zhao J, Chittiboyina AG, Meng Y, Wang M, Khan IA. Newly Generated Atractylon Derivatives in Processed Rhizomes of Atractylodes macrocephala Koidz. Molecules. 2020 Dec 13;25(24):5904. doi: 10.3390/molecules25245904. PMID: 33322214; PMCID: PMC7763829. 15: Satoh K, Nagai F, Ushiyama K, Kano I. Specific inhibition of Na+,K(+)-ATPase activity by atractylon, a major component of byaku-jutsu, by interaction with enzyme in the E2 state. Biochem Pharmacol. 1996 Feb 9;51(3):339-43. doi: 10.1016/0006-2952(95)02188-4. PMID: 8573201. 16: Gu Z, Nie X, Guo P, Lu Y, Chen B. Simultaneous Analysis of Hydrophobic Atractylenolides, Atractylon and Hydrophilic Sugars in Bai-Zhu Using a High- Performance Liquid Chromatography Column Tandem Technique. Foods. 2023 Oct 27;12(21):3931. doi: 10.3390/foods12213931. PMID: 37959050; PMCID: PMC10650456. 17: Hasada K, Yoshida T, Yamazaki T, Sugimoto N, Nishimura T, Nagatsu A, Mizukami H. Quantitative determination of atractylon in Atractylodis Rhizoma and Atractylodis Lanceae Rhizoma by 1H-NMR spectroscopy. J Nat Med. 2010 Apr;64(2):161-6. doi: 10.1007/s11418-010-0393-x. Epub 2010 Feb 19. PMID: 20165926. 18: HIKINO H, HIKINO Y, YOSIOKA I. Structure and autoxidation of atractylon. Chem Pharm Bull (Tokyo). 1962 Jul;10:641-2. doi: 10.1248/cpb.10.641. PMID: 13954450. 19: Cheng Y, Ping J, Chen J, Fu Y, Zhao H, Xue J. [Retracted] Molecular mechanism of atractylon in the invasion and migration of hepatic cancer cells based on high‑throughput sequencing. Mol Med Rep. 2025 Jan;31(1):8. doi: 10.3892/mmr.2024.13373. Epub 2024 Oct 25. PMID: 39450546. 20: Zhao C, He C. Preparative isolation and purification of atractylon and atractylenolide III from the Chinese medicinal plant atractylodes macrocephala by high-speed counter-current chromatography. J Sep Sci. 2006 Jul;29(11):1630-6. doi: 10.1002/jssc.200500464. PMID: 16922280.

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DNAC-1

DNAC-1