MedKoo Cat#: 128102 | Name: BNZ-111

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BNZ-111 is a tubulin inhibitor. BNZ-111 is potent to cancer cells and possesses good drug-like properties as oral drug. Especially, BNZ-111 is not a P-gp substrate and it demonstrates its efficacy over Paclitaxel-resistance tumor in vivo.

Chemical Structure

BNZ-111
BNZ-111
CAS#3022361-60-7

Theoretical Analysis

MedKoo Cat#: 128102

Name: BNZ-111

CAS#: 3022361-60-7

Chemical Formula: C13H16FN3O2

Exact Mass: 265.1227

Molecular Weight: 265.29

Elemental Analysis: C, 58.86; H, 6.08; F, 7.16; N, 15.84; O, 12.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BNZ-111; BNZ111; BNZ 111
IUPAC/Chemical Name
N-(5-fluoro-6-propoxy-1H-benzo[d]imidazol-2-yl)propionamide
InChi Key
WWTQYZLPRUDFOM-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H16FN3O2/c1-3-5-19-11-7-10-9(6-8(11)14)15-13(16-10)17-12(18)4-2/h6-7H,3-5H2,1-2H3,(H2,15,16,17,18)
SMILES Code
O=C(CC)NC1=NC2=CC(F)=C(OCCC)C=C2N1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 265.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jang J, Koh B, Lee K. Discovery of benzimidazole-2-amide BNZ-111 as new tubulin inhibitor. Bioorg Med Chem Lett. 2024 Nov 15;113:129953. doi: 10.1016/j.bmcl.2024.129953. Epub 2024 Sep 11. PMID: 39270806. 2: Koh B, Ryu JY, Noh JJ, Hwang JR, Choi JJ, Cho YJ, Jang J, Jo JH, Lee K, Lee JW. Anti-cancer effects of benzimidazole derivative BNZ-111 on paclitaxel- resistant ovarian cancer. Gynecol Oncol. 2024 Sep;188:60-70. doi: 10.1016/j.ygyno.2024.06.011. Epub 2024 Jun 26. PMID: 38936282.