MedKoo Cat#: 128099 | Name: KR-40795

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KR-40795 is a ATX inhibitor. KR-40795 demonstrated significant inhibition of both collagen formation and lipid accumulation in liver cells, suggesting its potential as a therapeutic agent for liver diseases, particularly fibrosis and steatosis

Chemical Structure

KR-40795
KR-40795
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128099

Name: KR-40795

CAS#: N/A

Chemical Formula: C26H22ClNO5

Exact Mass: 463.1187

Molecular Weight: 463.91

Elemental Analysis: C, 67.32; H, 4.78; Cl, 7.64; N, 3.02; O, 17.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KR-40795; KR 40795; KR40795
IUPAC/Chemical Name
methyl (Z)-4-(((6-((1-(3-chlorophenyl)-2,5-dioxopyrrolidin-3-ylidene)methyl)cyclohexa-1,5-dien-1-yl)oxy)methyl)benzoate
InChi Key
FAQYARKPYMVEQZ-MOSHPQCFSA-N
InChi Code
InChI=1S/C26H22ClNO5/c1-32-26(31)18-11-9-17(10-12-18)16-33-23-8-3-2-5-19(23)13-20-14-24(29)28(25(20)30)22-7-4-6-21(27)15-22/h4-13,15H,2-3,14,16H2,1H3/b20-13-
SMILES Code
ClC1=CC=CC(N2C(C/C(C2=O)=C/C3=CCCC=C3OCC4=CC=C(C(OC)=O)C=C4)=O)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 463.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Hyeong Lee S, Jin Park S, Young Lee M, Young Choi J, Dae Jang W, Jang J, Hyun Lee J, Jo Lim C, Oh KS. Design, synthesis and evaluation of 3-(2-(substituted benzyloxy)benzylidene) pyrrolidine-2,5-dione derivatives for novel ATX inhibitor. Bioorg Med Chem Lett. 2024 Oct 28;114:130006. doi: 10.1016/j.bmcl.2024.130006. Epub ahead of print. PMID: 39477127.