Synonym
TrkB Agonist Prodrug R13; TrkB-IN-1; Tropomyosin-related Kinase B Agonist Prodrug R13; Tropomyosin-related Kinase B Inhibitor 1;
IUPAC/Chemical Name
4-oxo-2-phenyl-4H-chromene-7,8-diyl bis(methylcarbamate)
InChi Key
NWWRHMSYZTWUBD-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H16N2O6/c1-20-18(23)26-14-9-8-12-13(22)10-15(11-6-4-3-5-7-11)25-16(12)17(14)27-19(24)21-2/h3-10H,1-2H3,(H,20,23)(H,21,24)
SMILES Code
O=C(NC)OC1=C(OC(C2=CC=CC=C2)=CC3=O)C3=CC=C1OC(NC)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
368.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Xiong J, Liao J, Liu X, Zhang Z, Adams J, Pacifici R, Ye K. A TrkB agonist
prodrug prevents bone loss via inhibiting asparagine endopeptidase and
increasing osteoprotegerin. Nat Commun. 2022 Aug 16;13(1):4820. doi:
10.1038/s41467-022-32435-5. PMID: 35973996; PMCID: PMC9381595.
2: Li T, Li X, Huang X, Yu H, Li S, Zhang Z, Xie Y, Song X, Liu J, Yang X, Liu
G. Mitochondriomics reveals the underlying neuroprotective mechanism of TrkB
receptor agonist R13 in the 5×FAD mice. Neuropharmacology. 2022 Feb
15;204:108899. doi: 10.1016/j.neuropharm.2021.108899. Epub 2021 Nov 25. PMID:
34838815.
3: Chen C, Wang Z, Zhang Z, Liu X, Kang SS, Zhang Y, Ye K. The prodrug of
7,8-dihydroxyflavone development and therapeutic efficacy for treating
Alzheimer's disease. Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):578-583. doi:
10.1073/pnas.1718683115. Epub 2018 Jan 2. PMID: 29295929; PMCID: PMC5777001.
4: Ren E, Roncacé V, Trazzi S, Fuchs C, Medici G, Gennaccaro L, Loi M, Galvani
G, Ye K, Rimondini R, Aicardi G, Ciani E. Functional and Structural Impairments
in the Perirhinal Cortex of a Mouse Model of CDKL5 Deficiency Disorder Are
Rescued by a TrkB Agonist. Front Cell Neurosci. 2019 Apr 30;13:169. doi:
10.3389/fncel.2019.00169. PMID: 31114483; PMCID: PMC6503158.
