Synonym
BPRMU191; BPRMU-191; BPRMU 191
IUPAC/Chemical Name
4-(2-(4-fluorophenyl)-4-oxothiazolidin-3-yl)-3-methylbenzoic acid
InChi Key
XFVROXANDOEHAV-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H14FNO3S/c1-10-8-12(17(21)22)4-7-14(10)19-15(20)9-23-16(19)11-2-5-13(18)6-3-11/h2-8,16H,9H2,1H3,(H,21,22)
SMILES Code
FC1=CC=C(C2N(C3=CC=C(C(O)=O)C=C3C)C(CS2)=O)C=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
331.36
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lin SY, Chang YC, Tien YW, Kuo YH, Chang HF, Ou LC, Chen YP, Chang KH, Hsu
YT, Huang YC, Yang CM, Law PY, Xi JH, Tao PL, Loh HH, Yeh TK, Zhuang H, Hsieh
HP, Shih C, Chen CT, Yeh SH, Ueng SH. DBPR116, a Prodrug of BPRMU191, in
Combination with Naltrexone as a Safer Opioid Analgesic Than Morphine via
Peripheral Administration. J Med Chem. 2024 Oct 29. doi:
10.1021/acs.jmedchem.4c02107. Epub ahead of print. PMID: 39473174.
2: Huang YH, Lin SY, Ou LC, Huang WC, Chao PK, Chang YC, Chang HF, Lee PT, Yeh
TK, Kuo YH, Tien YW, Xi JH, Tao PL, Chen PY, Chuang JY, Shih C, Chen CT, Tung
CW, Loh HH, Ueng SH, Yeh SH. Discovery of a mu-opioid receptor modulator that in
combination with morphinan antagonists induces analgesia. Cell Chem Biol. 2024
Jul 9:S2451-9456(24)00272-1. doi: 10.1016/j.chembiol.2024.06.013. Epub ahead of
print. PMID: 39025070.
