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MedKoo Cat#: 128047 | Name: DD205-291

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DD205-291 is a novel PROTAC-based HPK1 degrader with high selectivity and potency. DD205-291 showed a dose-dependent inhibition of SLP-76 phosphorylation and an induction of IL-2 and IFN-γ. Compared with other inhibitors, DD205-291 exhibited good efficacy and a favorable safety profile in the MC38 model. DD205-291 exhibited a low risk of cardiotoxicity and a wide safety window. DD205-291 is a promising preclinical candidate (PCC) for potential mono- and comboimmunotherapy of cancer.

Chemical Structure

DD205-291
DD205-291
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128047

Name: DD205-291

CAS#: N/A

Chemical Formula: C38H38ClF3N10O3

Exact Mass: 774.2769

Molecular Weight: 775.23

Elemental Analysis: C, 58.87; H, 4.94; Cl, 4.57; F, 7.35; N, 18.07; O, 6.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DD205-291; DD205291; DD205 291
IUPAC/Chemical Name
1-(2-chloro-5-(4-((1-(5-(7-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)pyridin-2-yl)piperidin-4-yl)methyl)piperidine-1-carbonyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione
InChi Key
NQZCBDOOYGTFSB-UHFFFAOYSA-N
InChi Code
InChI=1S/C38H38ClF3N10O3/c39-29-3-1-25(16-31(29)52-14-9-33(53)48-37(52)55)36(54)50-12-7-24(8-13-50)15-23-5-10-49(11-6-23)32-4-2-26(17-43-32)30-20-45-35-34(47-30)28(19-44-35)27-18-46-51(21-27)22-38(40,41)42/h1-4,16-21,23-24H,5-15,22H2,(H,44,45)(H,48,53,55)
SMILES Code
FC(F)(F)CN1N=CC(C2=CNC3=C2N=C(C4=CC=C(N5CCC(CC6CCN(C(C7=CC(N8CCC(NC8=O)=O)=C(Cl)C=C7)=O)CC6)CC5)N=C4)C=N3)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 775.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Zhang Z, Guo L, Zhao M, Pan H, Dong Z, Wang L, Yang X, Zhang Z, Wu M, Chang Y, Yang Y, Sun L, Liu S, Zhu R, Zheng H, Dai X, Zhang X, Jiang C, Zhu Z, Zhang Y, Liu D. Discovery of Novel PROTAC-Based HPK1 Degraders with High Potency and Selectivity for Cancer Immunotherapy. J Med Chem. 2024 Oct 24. doi: 10.1021/acs.jmedchem.4c01906. Epub ahead of print. PMID: 39446986.