MedKoo Cat#: 128046 | Name: MORF-627

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MORF-627 is a highly selective inhibitor of αvβ6 (IC50 = 1.1 nM) that stabilizes the bent-closed conformation and has good oral PK. MORF-627 is a useful tool compound for studying the biology of integrin αvβ6.

Chemical Structure

MORF-627
MORF-627
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128046

Name: MORF-627

CAS#: N/A

Chemical Formula: C31H40FN3O4

Exact Mass: 537.3003

Molecular Weight: 537.68

Elemental Analysis: C, 69.25; H, 7.50; F, 3.53; N, 7.82; O, 11.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MORF-627; MORF627; MORF 627
IUPAC/Chemical Name
(S)-2-(5-fluoro-2-((S)-5-oxaspiro[2.5]octan-6-yl)phenyl)-2-((R)-3-(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butoxy)pyrrolidin-1-yl)acetic acid
InChi Key
PFCLAPQUIKLTKZ-KGPYPHOUSA-N
InChi Code
InChI=1S/C31H40FN3O4/c32-22-7-9-25(27-10-12-31(13-14-31)20-39-27)26(18-22)28(30(36)37)35-16-11-24(19-35)38-17-2-1-5-23-8-6-21-4-3-15-33-29(21)34-23/h6-9,18,24,27-28H,1-5,10-17,19-20H2,(H,33,34)(H,36,37)/t24-,27+,28+/m1/s1
SMILES Code
FC1=CC=C([C@H]2OCC3(CC3)CC2)C([C@@H](C(O)=O)N(CC4)C[C@@H]4OCCCCC5=CC=C6C(NCCC6)=N5)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 537.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Harrison BA, Dowling JE, Bursavich MG, Troast DM, Chong KM, Hahn KN, Zhong C, Mulvihill KM, Nguyen H, Monroy MF, Qiao Q, Sosa B, Mostafavi S, Smukste I, Lee D, Cappellucci L, Konopka EH, Nowakowski P, Stawski L, Senices M, Nguyen MH, Kapoor PS, Luus L, Sullivan A, Bortolato A, Svensson M, Hickey ER, Konze KD, Day T, Kim B, Negri A, Gerasyuto AI, Moy TI, Lu M, Ray AS, Wang L, Cui D, Lin FY, Lippa B, Rogers BN. The Discovery of MORF-627, a Highly Selective Conformationally-Biased Zwitterionic Integrin αvβ6 Inhibitor for Fibrosis. J Med Chem. 2024 Oct 24. doi: 10.1021/acs.jmedchem.4c01851. Epub ahead of print. PMID: 39446989. 2: Guffroy M, Trela B, Kambara T, Stawski L, Chen H, Luus L, Montesinos MS, Olson L, He Y, Maisonave K, Carr T, Lu M, Ray AS, Hazelwood LA. Selective inhibition of integrin αvβ6 leads to rapid induction of urinary bladder tumors in cynomolgus macaques. Toxicol Sci. 2023 Feb 17;191(2):400-413. doi: 10.1093/toxsci/kfac128. Erratum in: Toxicol Sci. 2023 Mar 20;192(1):130. doi: 10.1093/toxsci/kfad011. PMID: 36515490; PMCID: PMC9936210.