BAY405 is a potent MAP4K1 Inhibitor for the Enhancement of T‑Cell Immunity against Cancer. BAY-405 displays nanomolar potency in biochemical and cellular assays as well as in vivo exposure after oral dosing. BAY-405 enhances T-cell immunity and overcomes the suppressive effect of PGE2 and TGFβ. Treatment of tumor-bearing mice shows T-celldependent antitumor efficacy. MAP4K1 inhibition in conjunction with PD-L1 blockade results in a superior antitumor impact, illustrating the complementarity of the single agent treatments.
MedKoo Cat#: 128027
Name: BAY-405
CAS#: N/A
Chemical Formula: C25H23F5N4O3
Exact Mass: 522.1690
Molecular Weight: 522.48
Elemental Analysis: C, 57.47; H, 4.44; F, 18.18; N, 10.72; O, 9.19
The following data is based on the product molecular weight 522.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
