M17-B15 | AR antagonist

MedKoo Cat#: 128025 | Name: M17-B15

Description:

WARNING: This product is for research use only, not for human or veterinary use.

M17-B15 is an AR antagonist. M17-B15 showed strong in vitro efficacy against PCa but had poor pharmacokinetic properties in vivo.

Chemical Structure

M17-B15

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128025

Name: M17-B15

CAS#: N/A

Chemical Formula: C18H14F3N3O3S

Exact Mass: 409.0708

Molecular Weight: 409.38

Elemental Analysis: C, 52.81; H, 3.45; F, 13.92; N, 10.26; O, 11.72; S, 7.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

M17-B15; M17 B15; M17B15

IUPAC/Chemical Name

2-methyl-N-(3-(2-oxopropyl)-1,2,4-thiadiazol-5-yl)-5-(3-(trifluoromethyl)phenyl)furan-3-carboxamide

InChi Key

VTTBPXATVITFMS-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H14F3N3O3S/c1-9(25)6-15-22-17(28-24-15)23-16(26)13-8-14(27-10(13)2)11-4-3-5-12(7-11)18(19,20)21/h3-5,7-8H,6H2,1-2H3,(H,22,23,24,26)

SMILES Code

CC(O1)=C(C(NC2=NC(CC(C)=O)=NS2)=O)C=C1C3=CC=CC(C(F)(F)F)=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 409.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fu W, Yang H, Hu C, Liao J, Gong Z, Zhang M, Yang S, Ye S, Lei Y, Sheng R, Zhang Z, Yao X, Tang C, Li D, Hou T. Small-Molecule Inhibition of Androgen Receptor Dimerization as a Strategy against Prostate Cancer. ACS Cent Sci. 2023 Mar 8;9(4):675-684. doi: 10.1021/acscentsci.2c01548. PMID: 37122451; PMCID: PMC10141604. 2: Liao J, Hu C, Fu W, Liao J, Chai X, Shan L, Xu X, Hou T, Sheng R, Li D. Discovery of Thiadiazoleamide Derivatives as Potent, Selective, and Orally Available Antagonists Disrupting Androgen Receptor Homodimer. J Med Chem. 2024 Oct 10;67(19):17520-17541. doi: 10.1021/acs.jmedchem.4c01464. Epub 2024 Sep 28. PMID: 39340456.