Met-DD4 is a c‑Met PROTAC for the Treatment of c‑Met-Addicted Cancer. Met-DD4 could induce robust c-Met degradation with excellent selectivity (DC50 = 6.21 nM), substantially killing the c-Met-addicted cancer cells (IC50 = 4.37 nM). Furthermore, in vivo studies showed that Met-DD4 could achieve excellent oral bioavailability and c-Met degradation, strongly retarding tumor growth with minute organ toxicity.
MedKoo Cat#: 128020
Name: Met-DD4
CAS#: N/A
Chemical Formula: C45H41FN10O5
Exact Mass: 820.3245
Molecular Weight: 820.89
Elemental Analysis: C, 65.84; H, 5.03; F, 2.31; N, 17.06; O, 9.74
The following data is based on the product molecular weight 820.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
