MedKoo Cat#: 128014 | Name: W-13 HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.

Chemical Structure

W-13 HCl
W-13 HCl
CAS#88519-57-7

Theoretical Analysis

MedKoo Cat#: 128014

Name: W-13 HCl

CAS#: 88519-57-7

Chemical Formula: C14H18Cl2N2O2S

Exact Mass: 0.0000

Molecular Weight: 349.27

Elemental Analysis: C, 48.14; H, 5.19; Cl, 20.30; N, 8.02; O, 9.16; S, 9.18

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
1g USD 4,450.00 2 Weeks
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Related CAS #
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Synonym
W-13 HCl; W-13; W13; W 13; W-13 (hydrochloride)
IUPAC/Chemical Name
N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide hydrochloride
InChi Key
QKAALLVQBOLELJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H17ClN2O2S.ClH/c15-14-5-3-4-11-10-12(6-7-13(11)14)20(18,19)17-9-2-1-8-16;/h3-7,10,17H,1-2,8-9,16H2;1H
SMILES Code
ClC1=C2C(C=C(S(NCCCCN)(=O)=O)C=C2)=CC=C1.Cl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 349.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wei JW, Hickie RA, Klaassen DJ. Inhibition of human breast cancer colony formation by anticalmodulin agents: trifluoperazine, W-7, and W-13. Cancer Chemother Pharmacol. 1983;11(2):86-90. doi: 10.1007/BF00254251. PMID: 6627600. 2: Sengupta P, Ruano MJ, Tebar F, Golebiewska U, Zaitseva I, Enrich C, McLaughlin S, Villalobo A. Membrane-permeable calmodulin inhibitors (e.g. W-7/W-13) bind to membranes, changing the electrostatic surface potential: dual effect of W-13 on epidermal growth factor receptor activation. J Biol Chem. 2007 Mar 16;282(11):8474-86. doi: 10.1074/jbc.M607211200. Epub 2007 Jan 16. PMID: 17227773.