MedKoo Cat#: 128004 | Name: H2-Gamendazole
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

H2-Gamendazole is a derivative of Lonidamine that reduces cyst formation in polycystic kidney disease and is used in autosomal dominant polycystic kidney disease research.

Chemical Structure

H2-Gamendazole
H2-Gamendazole
CAS#877768-84-8

Theoretical Analysis

MedKoo Cat#: 128004

Name: H2-Gamendazole

CAS#: 877768-84-8

Chemical Formula: C18H13Cl2F3N2O2

Exact Mass: 416.0306

Molecular Weight: 417.21

Elemental Analysis: C, 51.82; H, 3.14; Cl, 16.99; F, 13.66; N, 6.71; O, 7.67

Price and Availability

Size Price Availability Quantity
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
1g USD 4,650.00 2 Weeks
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Related CAS #
No Data
Synonym
H2-Gamendazole; H2Gamendazole; H2 Gamendazole
IUPAC/Chemical Name
3-(1-(2,4-dichlorobenzyl)-6-(trifluoromethyl)-1H-indazol-3-yl)propanoic acid
InChi Key
OMVYOEVUBVQVKZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H13Cl2F3N2O2/c19-12-3-1-10(14(20)8-12)9-25-16-7-11(18(21,22)23)2-4-13(16)15(24-25)5-6-17(26)27/h1-4,7-8H,5-6,9H2,(H,26,27)
SMILES Code
O=C(CCC1=NN(CC2=CC=C(C=C2Cl)Cl)C3=C1C=CC(C(F)(F)F)=C3)O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 417.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Sundar SV, Zhou JX, Magenheimer BS, Reif GA, Wallace DP, Georg GI, Jakkaraj SR, Tash JS, Yu ASL, Li X, Calvet JP. The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease. Am J Physiol Renal Physiol. 2022 Oct 1;323(4):F492-F506. doi: 10.1152/ajprenal.00095.2022. Epub 2022 Aug 18. PMID: 35979967; PMCID: PMC9529276.