MedKoo Cat#: 128002 | Name: TRPM4-IN-2
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM.

Chemical Structure

TRPM4-IN-2
TRPM4-IN-2
CAS#667411-04-3

Theoretical Analysis

MedKoo Cat#: 128002

Name: TRPM4-IN-2

CAS#: 667411-04-3

Chemical Formula: C19H14ClNO4

Exact Mass: 355.0611

Molecular Weight: 355.77

Elemental Analysis: C, 64.14; H, 3.97; Cl, 9.96; N, 3.94; O, 17.99

Price and Availability

Size Price Availability Quantity
25mg USD 550.00 2 Weeks
50mg USD 950.00 2 Weeks
100mg USD 1,450.00 2 Weeks
1g USD 5,450.00 2 Weeks
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Related CAS #
No Data
Synonym
TRPM4-IN-2; TRPM4 IN-2; TRPM4-IN 2; NBA
IUPAC/Chemical Name
4-chloro-2-(2-(naphthalen-1-yloxy)acetamido)benzoic acid
InChi Key
OKFVCWAYHJMQFA-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H14ClNO4/c20-13-8-9-15(19(23)24)16(10-13)21-18(22)11-25-17-7-3-5-12-4-1-2-6-14(12)17/h1-10H,11H2,(H,21,22)(H,23,24)
SMILES Code
O=C(O)C1=CC=C(Cl)C=C1NC(COC2=C3C=CC=CC3=CC=C2)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 355.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Borgström A, Hauert B, Kappel S, Zoni E, Kiener M, Stokłosa P, Baur R, Spahn M, Kruithof-de Julio M, Peinelt C. Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions. J Mol Biol. 2021 Aug 20;433(17):166665. doi: 10.1016/j.jmb.2020.09.024. Epub 2020 Oct 12. PMID: 33058873. 2. Stokłosa P, Borgström A, Hauert B, Baur R, Peinelt C. Investigation of Novel Small Molecular TRPM4 Inhibitors in Colorectal Cancer Cells. Cancers (Basel). 2021 Oct 28;13(21):5400. doi: 10.3390/cancers13215400. PMID: 34771564; PMCID: PMC8582472.