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MedKoo Cat#: 406210 | Name: AG1295
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AG1295 is a PDGF receptor specific inhibitor. AG1295 exerts a marked inhibitory effect on the activation, migration, and proliferation of porcine and human smooth muscle cells SMCs in vitro and an approximately 50% inhibitory effect on neointimal formation after balloon injury in porcine femoral arteries when delivered via biodegradable nanoparticles. Further studies appear to be warranted to evaluate the applicability of this novel approach to the interventional setting.

Chemical Structure

AG1295
CAS#71897-07-9

Theoretical Analysis

MedKoo Cat#: 406210

Name: AG1295

CAS#: 71897-07-9

Chemical Formula: C16H14N2

Exact Mass: 234.1157

Molecular Weight: 234.30

Elemental Analysis: C, 82.02; H, 6.02; N, 11.96

Price and Availability

Size Price Availability Quantity
10mg USD 450.00 2 Weeks
25mg USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
AG1295; AG-1295; AG 1295; NSC 380341; NSC380341; NSC-380341; Tyrphostin AG 1295; Tyrphostin AG1295; Tyrphostin AG-1295
IUPAC/Chemical Name
6,7-dimethyl-2-phenylquinoxaline
InChi Key
FQNCLVJEQCJWSU-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H14N2/c1-11-8-14-15(9-12(11)2)18-16(10-17-14)13-6-4-3-5-7-13/h3-10H,1-2H3
SMILES Code
CC1=C(C)C=C2N=CC(C3=CC=CC=C3)=NC2=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>5 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
        

Preparing Stock Solutions

The following data is based on the product molecular weight 234.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PMID: 9609090. 4: Iwamoto H, Nakamuta M, Tada S, Sugimoto R, Enjoji M, Nawata H. Platelet- derived growth factor receptor tyrosine kinase inhibitor AG1295 attenuates rat hepatic stellate cell growth. J Lab Clin Med. 2000 May;135(5):406-12. doi: 10.1067/mlc.2000.105974. PMID: 10811056. 5: Pascuali N, Scotti L, Abramovich D, Irusta G, Di Pietro M, Bas D, Tesone M, Parborell F. Inhibition of platelet-derived growth factor (PDGF) receptor affects follicular development and ovarian proliferation, apoptosis and angiogenesis in prepubertal eCG-treated rats. Mol Cell Endocrinol. 2015 Sep 5;412:148-58. doi: 10.1016/j.mce.2015.04.021. Epub 2015 Apr 29. PMID: 25937181. 6: Jiao Y, Preston S, Hofmann A, Taki A, Baell J, Chang BCH, Jabbar A, Gasser RB. A perspective on the discovery of selected compounds with anthelmintic activity against the barber's pole worm-Where to from here? Adv Parasitol. 2020;108:1-45. doi: 10.1016/bs.apar.2019.12.003. Epub 2020 Mar 4. PMID: 32291083. 7: Liu Y, Luo Q, Qiang Q, Wang H, Ding Y, Wang C, Xiao J, Li C, Zhang T. Successive Cleavage and Reconstruction of Lignin β-O-4 Models and Polymer to Access Quinoxalines. ChemSusChem. 2022 Nov 8;15(21):e202201401. doi: 10.1002/cssc.202201401. Epub 2022 Sep 23. PMID: 36055966. 8: Jiang Z, Zhong G, Wen L, Hong Y, Fang S, Sun P, Li S, Li S, Feng G. The Role of Platelet-Derived Growth Factor-B/Platelet-Derived Growth Factor Receptor-β Signaling in Chronic Atrial Fibrillation. Cardiology. 2016;133(4):242-56. doi: 10.1159/000442940. Epub 2016 Jan 12. PMID: 26752520. 9: Kim JO, Baek SE, Jeon EY, Choi JM, Jang EJ, Kim CD. PDGFR-β signaling mediates HMGB1 release in mechanically stressed vascular smooth muscle cells. PLoS One. 2022 Mar 16;17(3):e0265191. doi: 10.1371/journal.pone.0265191. PMID: 35294955; PMCID: PMC8926240. 10: Saito Y, Yamaguchi A, Nakamura S, Okuyoshi H, Shimazawa M, Hara H. Contribution of platelet-derived growth factor signaling to retina regeneration in zebrafish. Neurosci Lett. 2020 May 14;727:134930. doi: 10.1016/j.neulet.2020.134930. Epub 2020 Apr 3. PMID: 32251708. 11: Han Y, Adeyemi OS, Kabir MHB, Kato K. Screening of compound libraries for inhibitors of Toxoplasma growth and invasion. Parasitol Res. 2020 May;119(5):1675-1681. doi: 10.1007/s00436-020-06673-9. Epub 2020 Apr 1. PMID: 32236711; PMCID: PMC7223663. 12: Jiao Y, Preston S, Garcia-Bustos JF, Baell JB, Ventura S, Le T, McNamara N, Nguyen N, Botteon A, Skinner C, Danne J, Ellis S, Koehler AV, Wang T, Chang BCH, Hofmann A, Jabbar A, Gasser RB. Tetrahydroquinoxalines induce a lethal evisceration phenotype in Haemonchus contortus in vitro. Int J Parasitol Drugs Drug Resist. 2019 Apr;9:59-71. doi: 10.1016/j.ijpddr.2018.12.007. Epub 2018 Dec 30. PMID: 30690282; PMCID: PMC6357688. 13: Uren A, Merchant MS, Sun CJ, Vitolo MI, Sun Y, Tsokos M, Illei PB, Ladanyi M, Passaniti A, Mackall C, Toretsky JA. Beta-platelet-derived growth factor receptor mediates motility and growth of Ewing's sarcoma cells. Oncogene. 2003 Apr 17;22(15):2334-42. doi: 10.1038/sj.onc.1206330. PMID: 12700668. 14: Almiron Bonnin DA, Ran C, Havrda MC, Liu H, Hitoshi Y, Zhang Z, Cheng C, Ung M, Israel MA. Insulin-Mediated Signaling Facilitates Resistance to PDGFR Inhibition in Proneural hPDGFB-Driven Gliomas. Mol Cancer Ther. 2017 Apr;16(4):705-716. doi: 10.1158/1535-7163.MCT-16-0616. Epub 2017 Jan 30. PMID: 28138037. 15: Levis M, Tse KF, Smith BD, Garrett E, Small D. A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations. Blood. 2001 Aug 1;98(3):885-7. doi: 10.1182/blood.v98.3.885. PMID: 11468194. 16: Descorbeth M, Anand-Srivastava MB. Role of growth factor receptor transactivation in high glucose-induced increased levels of Gq/11alpha and signaling in vascular smooth muscle cells. J Mol Cell Cardiol. 2010 Aug;49(2):221-33. doi: 10.1016/j.yjmcc.2009.12.010. Epub 2009 Dec 28. PMID: 20036247. 17: Naraghi S, Khoshyomn S, DeMattia JA, Vane DW. Receptor tyrosine kinase inhibition suppresses growth of pediatric renal tumor cells in vitro. J Pediatr Surg. 2000 Jun;35(6):884-90. doi: 10.1053/jpsu.2000.6907. PMID: 10873031. 18: Salvador-Silva M, Aoi S, Parker A, Yang P, Pecen P, Hernandez MR. Responses and signaling pathways in human optic nerve head astrocytes exposed to hydrostatic pressure in vitro. Glia. 2004 Mar;45(4):364-77. doi: 10.1002/glia.10342. PMID: 14966868. 19: Di Girolamo N, Wakefield D, Coroneo MT. UVB-mediated induction of cytokines and growth factors in pterygium epithelial cells involves cell surface receptors and intracellular signaling. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2430-7. doi: 10.1167/iovs.05-1130. PMID: 16723453. 20: Mondorf UF, Geiger H, Herrero M, Zeuzem S, Piiper A. Involvement of the platelet-derived growth factor receptor in angiotensin II-induced activation of extracellular regulated kinases 1 and 2 in human mesangial cells. FEBS Lett. 2000 Apr 21;472(1):129-32. doi: 10.1016/s0014-5793(00)01433-2. PMID: 10781819.