MedKoo Cat#: 127943 | Name: Wu-5
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Wu-5 is a USP10 inhibitor that can inhibit FLT3 and AMPK pathways, induce FLT3-ITD degradation and induce apoptosis.

Chemical Structure

Wu-5
Wu-5
CAS#2630378-05-9

Theoretical Analysis

MedKoo Cat#: 127943

Name: Wu-5

CAS#: 2630378-05-9

Chemical Formula: C15H13NO7S

Exact Mass: 351.0413

Molecular Weight: 351.33

Elemental Analysis: C, 51.28; H, 3.73; N, 3.99; O, 31.88; S, 9.13

Price and Availability

Size Price Availability Quantity
25mg USD 750.00 2 Weeks
100mg USD 1,950.00 2 Weeks
1g USD 4,850.00 2 Weeks
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Related CAS #
No Data
Synonym
Wu-5; Wu5; Wu 5
IUPAC/Chemical Name
ethyl 5-(4-(methoxycarbonyl)phenoxy)-4-nitrothiophene-2-carboxylate
InChi Key
ZOBORTAJZNJCLJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H13NO7S/c1-3-22-14(18)12-8-11(16(19)20)15(24-12)23-10-6-4-9(5-7-10)13(17)21-2/h4-8H,3H2,1-2H3
SMILES Code
O=C(C1=CC=C(C=C1)OC2=C([N+]([O-])=O)C=C(C(OCC)=O)S2)OC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 351.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Yu M, Fang ZX, Wang WW, Zhang Y, Bu ZL, Liu M, Xiao XH, Zhang ZL, Zhang XM, Cao Y, Wang YY, Lei H, Xu HZ, Wu YZ, Liu W, Wu YL. Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways. Acta Pharmacol Sin. 2021 Apr;42(4):604-612. doi: 10.1038/s41401-020-0455-x. Epub 2020 Jul 21. PMID: 32694757; PMCID: PMC8115260.