Synonym
TM2-115; TM2115; TM2 115
IUPAC/Chemical Name
7-(benzyloxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
InChi Key
BSZDSEMSNHXVRW-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H38N6O2/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-20-21-8-5-4-6-9-21)25(35-3)18-23(24)27(31-28)29-22-10-14-33(2)15-11-22/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31)
SMILES Code
CN1CCC(NC2=C3C=C(OC)C(OCC4=CC=CC=C4)=CC3=NC(N5CCN(C)CCC5)=N2)CC1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
490.65
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Malmquist NA, Moss TA, Mecheri S, Scherf A, Fuchter MJ. Small-molecule
histone methyltransferase inhibitors display rapid antimalarial activity against
all blood stage forms in Plasmodium falciparum. Proc Natl Acad Sci U S A. 2012
Oct 9;109(41):16708-13. doi: 10.1073/pnas.1205414109. Epub 2012 Sep 24. PMID:
23011794; PMCID: PMC3478629.
2: Malmquist NA, Sundriyal S, Caron J, Chen P, Witkowski B, Menard D, Suwanarusk
R, Renia L, Nosten F, Jiménez-Díaz MB, Angulo-Barturen I, Santos Martínez M,
Ferrer S, Sanz LM, Gamo FJ, Wittlin S, Duffy S, Avery VM, Ruecker A, Delves MJ,
Sinden RE, Fuchter MJ, Scherf A. Histone methyltransferase inhibitors are orally
bioavailable, fast-acting molecules with activity against different species
causing malaria in humans. Antimicrob Agents Chemother. 2015 Feb;59(2):950-9.
doi: 10.1128/AAC.04419-14. Epub 2014 Nov 24. PMID: 25421480; PMCID: PMC4335868.
