CN-CC-861 is a Broad-Spectrum, Resistance-Breaking Antibiotic. CN-CC-861, carrying a prop-argyl side chain, had more than 16-fold lower minimal inhibitory concentration (MIC) values against Enterococcus faecalis, Staph-ylococci and Acine to bacter strains, compared to known analogues. Moreover, CN-CC-861 retained activity against multidrug-resistant enterococci, displayed strong bactericidal activity, moderate-low frequencies of resistance and in vivo efficacy in a neutropenic thigh infection model with E. coli. Overall, the findings will guide the design of new promising structures with higher activities and broader spectrum.
MedKoo Cat#: 127886
Name: CN-CC-861
CAS#: N/A
Chemical Formula: C44H36N6O9
Exact Mass: 792.2544
Molecular Weight: 792.81
Elemental Analysis: C, 66.66; H, 4.58; N, 10.60; O, 18.16
The following data is based on the product molecular weight 792.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
