JANEX-1-M | CAS#406484-24-0 | JAK inhibitor

MedKoo Cat#: 145538 | Name: JANEX-1-M

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JANEX-1 is a JAK inhibitor. JANEX-1 is metabolized by the cytochrome P450 enzymes CYP1A1 and CYP1A2. The formation of JANEX-1-M in the presence of baculovirus-expressed CYP1A1 and 1A2 is consistent with Michaelis-Menten kinetics.

Chemical Structure

JANEX-1-M

CAS#406484-24-0

Theoretical Analysis

MedKoo Cat#: 145538

Name: JANEX-1-M

CAS#: 406484-24-0

Chemical Formula: C15H13N3O3

Exact Mass: 283.1000

Molecular Weight: 283.29

Elemental Analysis: C, 63.60; H, 4.63; N, 14.83; O, 16.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JANEX-1-M; JANEX1M; JANEX 1 M; 7-O-DEMETHYLJANEX-1;

IUPAC/Chemical Name

4-((4-hydroxyphenyl)amino)-6-methoxyquinazolin-7-ol

InChi Key

WKTLTDLVYQTHFO-UHFFFAOYSA-N

InChi Code

1S/C15H13N3O3/c1-21-14-6-11-12(7-13(14)20)16-8-17-15(11)18-9-2-4-10(19)5-3-9/h2-8,19-20H,1H3,(H,16,17,18)

SMILES Code

COC1=CC2=C(NC3=CC=C(O)C=C3)N=CN=C2C=C1O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 283.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Uckun FM, Thoen J, Chen H, Sudbeck E, Mao C, Malaviya R, Liu XP, Chen CL. CYP1A-mediated metabolism of the Janus kinase-3 inhibitor 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: structural basis for inactivation by regioselective O-demethylation. Drug Metab Dispos. 2002 Jan;30(1):74-85. doi: 10.1124/dmd.30.1.74. PMID: 11744615.