PF-07328948 is a potent and selective inhibitor of branched-chain ketoacid dehydrogenase kinase (BDK) with an IC₅₀ of 15 nM. In vitro studies show that it acts as a BDK degrader, leading to sustained inhibition of BDK activity and a reduction in branched-chain amino acid (BCAA) levels. The compound exhibits a human hepatocyte clearance (HHEP Cl) rate of 31 μL/min/million cells, indicating favorable metabolic stability. Cellular assays confirm its ability to lower BCAA and ketoacid concentrations, supporting its potential therapeutic application in metabolic disorders, including heart failure.
MedKoo Cat#: 127782
Name: PF-07328948
CAS#: 2936625-34-0
Chemical Formula: C16H8F4O3S
Exact Mass: 356.0130
Molecular Weight: 356.29
Elemental Analysis: C, 53.94; H, 2.26; F, 21.33; O, 13.47; S, 9.00
The following data is based on the product molecular weight 356.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
