CEP1347-VHL-02 is a selective MLK3 Degrader. CEP1347-VHL-02 robustly degraded MLK3 and inhibited its oncogenic activity in TNBC, measured as a reduction of clonogenic and migratory potential, cell cycle arrest, and the induction of apoptosis in MDA-MB-468 cells.
MedKoo Cat#: 127738
Name: CEP1347-VHL-02
CAS#: N/A
Chemical Formula: C63H76N8O11S3
Exact Mass: 1216.4796
Molecular Weight: 1217.53
Elemental Analysis: C, 62.15; H, 6.29; N, 9.20; O, 14.45; S, 7.90
The following data is based on the product molecular weight 1,217.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
