HD2 is a potent DCN1 inhibitor (IC50= 2.96 nM) with favorable PK properties and low toxicity. Amazingly, HD2 effectively relieved Ang II/ TGFβ-induced cardiac fibroblast activation in vitro, and reduced ISO-induced cardiac fibrosis as well as remodeling in vivo, which was linked to the inhibition of cullin 3 neddylation and its substrate Nrf2 accumulation.
MedKoo Cat#: 127662
Name: HD2
CAS#: N/A
Chemical Formula: C18H14ClF3N4OS
Exact Mass: 426.0529
Molecular Weight: 426.84
Elemental Analysis: C, 50.65; H, 3.31; Cl, 8.31; F, 13.35; N, 13.13; O, 3.75; S, 7.51
The following data is based on the product molecular weight 426.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
