DD202-114 is a potent and selective GLP1R agonist (EC50 = 0.03 nM). DD202-114 demonstrates full agonistic efficacy in promoting cAMP accumulation and possesses favorable drug-like characteristics compared to the clinical drug candidate Danuglipron. Additionally, in hGLP-1R knock-in mice, DD202-114 displayed a sustained pharmacological effect, effectively reducing blood glucose levels and food intake.
MedKoo Cat#: 127652
Name: DD202-114
CAS#: N/A
Chemical Formula: C33H35FN4O5
Exact Mass: 586.2591
Molecular Weight: 586.66
Elemental Analysis: C, 67.56; H, 6.01; F, 3.24; N, 9.55; O, 13.64
The following data is based on the product molecular weight 586.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
