Nic-15 | nicolaioidesin C derivative | MIA PaCa-2 inhibitor

MedKoo Cat#: 127619 | Name: Nic-15

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nic-15 is a nicolaioidesin C derivative and a MIA PaCa-2 inhibitor. Nic-15 exhibited superior cytotoxicity against MIA PaCa-2 and PANC-1 pancreatic cancer cells, inhibited MIA PaCa-2 cell migration and colony formation, and modulatedthe PI3K/Akt/mTOR pathway, while reducing the ER stress markers induced bygemcitabine. Nic-15 was found to inhibit tumor growth and enhance the efficacy ofgemcitabine in an in vivo xenograft model. Nic-15 in combination with gemcitabine maybe an effective strategy for the treatment of pancreatic cancer.

Chemical Structure

Nic-15

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 127619

Name: Nic-15

CAS#: N/A

Chemical Formula: C25H26F2O3

Exact Mass: 412.1850

Molecular Weight: 412.48

Elemental Analysis: C, 72.80; H, 6.35; F, 9.21; O, 11.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Nic-15; Nic 15; Nic15

IUPAC/Chemical Name

((1S,2S)-2',3'-difluoro-5-(4-methylpent-3-en-1-yl)-1,2,3,6-tetrahydro-[1,1'-biphenyl]-2-yl)(2,6-dihydroxyphenyl)methanone

InChi Key

YUBNUKLPDZRGOV-RBUKOAKNSA-N

InChi Code

InChI=1S/C25H26F2O3/c1-15(2)6-3-7-16-12-13-18(25(30)23-21(28)10-5-11-22(23)29)19(14-16)17-8-4-9-20(26)24(17)27/h4-6,8-12,18-19,28-29H,3,7,13-14H2,1-2H3/t18-,19+/m0/s1

SMILES Code

OC1=CC=CC(O)=C1C([C@@H]2[C@@H](C3=CC=CC(F)=C3F)CC(CC/C=C(C)/C)=CC2)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 412.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Yamazaki T, Phan ND, Maneenet J, Yamagishi M, Nishikawa Y, Okada T, Okumura T, Toyooka N, Fujii T, Awale S. Targeting Pancreatic Cancer with Novel Nicolaioidesin C Derivatives: Molecular Mechanism, In Vitro, and In Vivo Evaluations. J Med Chem. 2024 Aug 6. doi: 10.1021/acs.jmedchem.4c01141. Epub ahead of print. PMID: 39106150.