Synonym
VLX-1005; VLX1005; VLX 1005; ML-355; ML355; ML 355;
IUPAC/Chemical Name
N-(benzo[d]thiazol-2-yl)-4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide
InChi Key
OWHBVKBNNRYMIN-UHFFFAOYSA-N
InChi Code
1S/C21H19N3O4S2/c1-28-18-7-4-5-14(20(18)25)13-22-15-9-11-16(12-10-15)30(26,27)24-21-23-17-6-2-3-8-19(17)29-21/h2-12,22,25H,13H2,1H3,(H,23,24)
SMILES Code
COC1=CC=CC(CNC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4S3)=C1O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
441.52
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Larsen HJ, Byrne D, Özpolat T, Chauhan A, Bailey SL, Rhoads N, Reed F, Stolla MC, Adili R, Holinstat M, Fu X, Stolla M. Loss of 12-Lipoxygenase Improves the Post-Transfusion Function of Stored Platelets. Arterioscler Thromb Vasc Biol. 2023 Oct;43(10):1990-2007. doi: 10.1161/ATVBAHA.123.319021. Epub 2023 Aug 31. PMID: 37650322; PMCID: PMC10538391.
2: Renna SA, Zhao X, Kunapuli SP, Ma P, Holinstat M, Boxer MB, Maloney DJ, Michael JV, McKenzie SE. Novel Strategy to Combat the Procoagulant Phenotype in Heparin-Induced Thrombocytopenia Using 12-LOX Inhibition. Arterioscler Thromb Vasc Biol. 2023 Oct;43(10):1808-1817. doi: 10.1161/ATVBAHA.123.319434. Epub 2023 Jun 22. PMID: 37345522.
3: Nargis T, Muralidharan C, Enriquez JR, Wang JE, Kaylan K, Chakraborty A, Pratuangtham S, Figatner K, Nelson JB, May SC, Nadler JL, Boxer MB, Maloney DJ, Tersey SA, Mirmira RG. 12-Lipoxygenase inhibition suppresses islet immune and inflammatory responses and delays autoimmune diabetes in human gene replacement mice. bioRxiv [Preprint]. 2024 Jul 28:2024.07.28.604986. doi: 10.1101/2024.07.28.604986. PMID: 39091839; PMCID: PMC11291127.
