LY-295501 | CAS#150869-74-2 | Diarylsulfonylurea

MedKoo Cat#: 150181 | Name: LY-295501

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY-295501 is a diarylsulfonylurea with potential antitumor activity both in vivo and in vitro. It was being developed for the treatment of solid malignancies.

Chemical Structure

LY-295501

CAS#150869-74-2

Theoretical Analysis

MedKoo Cat#: 150181

Name: LY-295501

CAS#: 150869-74-2

Chemical Formula: C15H12Cl2N2O4S

Exact Mass: 385.9890

Molecular Weight: 387.23

Elemental Analysis: C, 46.53; H, 3.12; Cl, 18.31; N, 7.23; O, 16.53; S, 8.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

LY-295501; ILX-295501; ly295501;

IUPAC/Chemical Name

1-(3,4-dichlorophenyl)-3-(2,3-dihydro-1-benzofuran-5-ylsulfonyl)urea

InChi Key

VAMFSFIPDOODFH-UHFFFAOYSA-N

InChi Code

1S/C15H12Cl2N2O4S/c16-12-3-1-10(8-13(12)17)18-15(20)19-24(21,22)11-2-4-14-9(7-11)5-6-23-14/h1-4,7-8H,5-6H2,(H2,18,19,20)

SMILES Code

O=C(NS(=O)(C1=CC2=C(OCC2)C=C1)=O)NC3=CC=C(Cl)C(Cl)=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 387.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Von Hoff DD. Promising new agents for treatment of patients with colorectal cancer. Semin Oncol. 1998 Oct;25(5 Suppl 11):47-52. PMID: 9786316. 2: Houghton PJ, Houghton JA. Antitumor diarylsulfonylureas: novel agents with unfulfilled promise. Invest New Drugs. 1996;14(3):271-80. doi: 10.1007/BF00194530. PMID: 8958182. 3: Schultz BD, Takahashi A, Liu C, Frizzell RA, Howard M. FLAG epitope positioned in an external loop preserves normal biophysical properties of CFTR. Am J Physiol. 1997 Dec;273(6):C2080-9. doi: 10.1152/ajpcell.1997.273.6.C2080. PMID: 9435515. 4: Houghton PJ, Cheshire PJ, Myers L, Lutz L, Toth J, Grindey GB, Houghton JA. Efficacy of sulofenur and a second generation diarylsulfonylurea, N-[5-(2,3-dihydrobenzofuryl)sulfonyl]-N'-(3,4-dichlorophenyl)urea (LY295501), against colon adenocarcinoma xenografts. Anticancer Drugs. 1995 Apr;6(2):317-23. doi: 10.1097/00001813-199504000-00017. PMID: 7795279.