MedKoo Cat#: 150177 | Name: Terbufibrol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Terbufibrol is an antihyperlipoproteinemic agent that blocks the hepatic cholesterol synthesis in a step between acetate and HMG-CoA. Animal studies show that terbufibrol is 10 times more active than clofibrate in reducing serum total cholesterol.

Chemical Structure

Terbufibrol
Terbufibrol
CAS#56488-59-6

Theoretical Analysis

MedKoo Cat#: 150177

Name: Terbufibrol

CAS#: 56488-59-6

Chemical Formula: C20H24O5

Exact Mass: 344.1620

Molecular Weight: 344.41

Elemental Analysis: C, 69.75; H, 7.02; O, 23.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Terbufibrol [INN]; Terbufibrol;
IUPAC/Chemical Name
4-[3-(4-tert-butylphenoxy)-2-hydroxypropoxy]benzoic acid
InChi Key
PXODZCMXOZRVEN-UHFFFAOYSA-N
InChi Code
1S/C20H24O5/c1-20(2,3)15-6-10-18(11-7-15)25-13-16(21)12-24-17-8-4-14(5-9-17)19(22)23/h4-11,16,21H,12-13H2,1-3H3,(H,22,23)
SMILES Code
O=C(O)C1=CC=C(OCC(O)COC2=CC=C(C(C)(C)C)C=C2)C=C1
Appearance
To be determined
Purity
97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 344.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Löser R, Schliack M, Moreth W. Mode of action of terbufibrol (INN) a hypolipidemic agent on rat liver sterol synthesis. Artery. 1982;10(3):180-92. PMID: 7201785. 2: Howard AN, Zschocke R, Löser R, Hofrichter G. The hypocholesterolemic effect of terbufibrol and other drugs in normal and hypercholesterolemic baboons. Atherosclerosis. 1979 Apr;32(4):367-80. doi: 10.1016/0021-9150(79)90004-2. PMID: 223594.