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MedKoo Cat#: 150171 | Name: 3,4-Dihydrocoumarin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dihydrocoumarin is a concentrated aromatic and flavor ingredient derived from Melilotus officinalis which may be used in flavor and fragrance compounds.

Chemical Structure

3,4-Dihydrocoumarin
3,4-Dihydrocoumarin
CAS#119-84-6

Theoretical Analysis

MedKoo Cat#: 150171

Name: 3,4-Dihydrocoumarin

CAS#: 119-84-6

Chemical Formula: C9H8O2

Exact Mass: 148.0520

Molecular Weight: 148.16

Elemental Analysis: C, 72.96; H, 5.44; O, 21.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
dihydrocoumarin; 3,4-dihydrocoumarin; hydrocoumarin; chroman-2-one;
IUPAC/Chemical Name
3,4-dihydrochromen-2-one
InChi Key
VMUXSMXIQBNMGZ-UHFFFAOYSA-N
InChi Code
1S/C9H8O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-4H,5-6H2
SMILES Code
O=C1CCC2=C(O1)C=CC=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 148.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Xie CC, Zhang BP, Wang HN, Li WY, Cai ZL, He Y, Ji K, Chen JJ. Flavoring agent dihydrocoumarin alleviates IgE-mediated mast cell activation and allergic inflammation. Food Funct. 2022 Mar 21;13(6):3621-3631. doi: 10.1039/d2fo00190j. PMID: 35262138. 2: Chen CC, Huang JS, Wang TH, Kuo CH, Wang CJ, Wang SH, Leu YL. Dihydrocoumarin, an HDAC Inhibitor, Increases DNA Damage Sensitivity by Inhibiting Rad52. Int J Mol Sci. 2017 Dec 7;18(12):2655. doi: 10.3390/ijms18122655. PMID: 29215575; PMCID: PMC5751257. 3: Yang H, Zhou S, Wu L, Wang L. Interference of Dihydrocoumarin with Hormone Transduction and Phenylpropanoid Biosynthesis Inhibits Barnyardgrass (Echinochloa crus-galli) Root Growth. Plants (Basel). 2022 Sep 26;11(19):2505. doi: 10.3390/plants11192505. PMID: 36235371; PMCID: PMC9572682. 4: Hou HM, Jiang F, Zhang GL, Wang JY, Zhu YH, Liu XY. Inhibition of Hafnia alvei H4 Biofilm Formation by the Food Additive Dihydrocoumarin. J Food Prot. 2017 May 1;80(5):842-847. doi: 10.4315/0362-028X.JFP-16-460. PMID: 28402186. 5: Api AM, Belsito D, Botelho D, Bruze M, Burton GA Jr, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y. RIFM fragrance ingredient safety assessment, dihydrocoumarin, CAS Registry Number 119-84-6. Food Chem Toxicol. 2021 Oct;156 Suppl 1:112557. doi: 10.1016/j.fct.2021.112557. Epub 2021 Sep 20. PMID: 34555462. 6: Wang Y , Han J , Xu Y , Gao Y , Wen H , Cui H . Taking advantage of the aromatisation of 7-diethylamino-4-methyl-3,4-dihydrocoumarin in the fluorescence sensing of superoxide anion. Chem Commun (Camb). 2020 Sep 4;56(68):9827-9829. doi: 10.1039/d0cc02282a. Epub 2020 Jul 27. PMID: 32716414. 7: Wang X, Xu J, Ji R, Bian H, Feng X, Jiang Z, Guo X, Zhang Y, Abdalla AN. Detection of Dihydrocoumarin in Coconut Juice via Photoelectric Detection System Based on Ultraviolet Absorption Spectrometry. Sensors (Basel). 2022 Oct 28;22(21):8267. doi: 10.3390/s22218267. PMID: 36365963; PMCID: PMC9653897.