Synonym
CI 976; CI-976; PD 128042; CI976; PD128042; PD-128042;
IUPAC/Chemical Name
2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
InChi Key
WAFNZAURAWBNDZ-UHFFFAOYSA-N
InChi Code
1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)
SMILES Code
CCCCCCCCCCC(C)(C)C(NC1=C(OC)C=C(OC)C=C1OC)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
393.57
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Baba T, Yamamoto A, Tagaya M, Tani K. A lysophospholipid acyltransferase antagonist, CI-976, creates novel membrane tubules marked by intracellular phospholipase A1 KIAA0725p. Mol Cell Biochem. 2013 Apr;376(1-2):151-61. doi: 10.1007/s11010-013-1563-4. Epub 2013 Feb 2. PMID: 23378048.
2: Brown WJ, Plutner H, Drecktrah D, Judson BL, Balch WE. The lysophospholipid acyltransferase antagonist CI-976 inhibits a late step in COPII vesicle budding. Traffic. 2008 May;9(5):786-97. doi: 10.1111/j.1600-0854.2008.00711.x. Epub 2008 Mar 4. PMID: 18331383; PMCID: PMC2432463.
3: Krause BR, Anderson M, Bisgaier CL, Bocan T, Bousley R, DeHart P, Essenburg A, Hamelehle K, Homan R, Kieft K, et al. In vivo evidence that the lipid- regulating activity of the ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT. J Lipid Res. 1993 Feb;34(2):279-94. PMID: 8429262.
4: Chambers K, Judson B, Brown WJ. A unique lysophospholipid acyltransferase (LPAT) antagonist, CI-976, affects secretory and endocytic membrane trafficking pathways. J Cell Sci. 2005 Jul 15;118(Pt 14):3061-71. doi: 10.1242/jcs.02435. Epub 2005 Jun 21. PMID: 15972316.
5: Bocan TM, Mueller SB, Uhlendorf PD, Newton RS, Krause BR. Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. A biochemical, morphological, and morphometric evaluation. Arterioscler Thromb. 1991 Nov-Dec;11(6):1830-43. doi: 10.1161/01.atv.11.6.1830. PMID: 1931885.
