Synonym
paraxanthine; 1,7-Dimethylxanthine; p-Xanthine;
IUPAC/Chemical Name
1,7-dimethyl-3H-purine-2,6-dione
InChi Key
QUNWUDVFRNGTCO-UHFFFAOYSA-N
InChi Code
1S/C7H8N4O2/c1-10-3-8-5-4(10)6(12)11(2)7(13)9-5/h3H,1-2H3,(H,9,13)
SMILES Code
O=C(N1C)NC2=C(N(C)C=N2)C1=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
180.17
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Szlapinski SK, Charrette A, Guthrie N, Hilmas CJ. Paraxanthine safety and comparison to caffeine. Front Toxicol. 2023 Feb 2;5:1117729. doi: 10.3389/ftox.2023.1117729. PMID: 36818692; PMCID: PMC9932512.
2: Jäger R, Purpura M, Wells SD, Liao K, Godavarthi A. Paraxanthine Supplementation Increases Muscle Mass, Strength, and Endurance in Mice. Nutrients. 2022 Feb 20;14(4):893. doi: 10.3390/nu14040893. PMID: 35215543; PMCID: PMC8875973.
3: Purkiewicz A, Pietrzak-Fiećko R, Sörgel F, Kinzig M. Caffeine, Paraxanthine, Theophylline, and Theobromine Content in Human Milk. Nutrients. 2022 May 25;14(11):2196. doi: 10.3390/nu14112196. PMID: 35683994; PMCID: PMC9182860.
4: Yoo C, Xing D, Gonzalez DE, Jenkins V, Nottingham K, Dickerson B, Leonard M, Ko J, Lewis MH, Faries M, Kephart W, Purpura M, Jäger R, Wells SD, Liao K, Sowinski R, Rasmussen CJ, Kreider RB. Paraxanthine provides greater improvement in cognitive function than caffeine after performing a 10-km run. J Int Soc Sports Nutr. 2024 Dec;21(1):2352779. doi: 10.1080/15502783.2024.2352779. Epub 2024 May 9. PMID: 38725238; PMCID: PMC11089923.
5: Shen J, Ye Y, Chang DW, Huang M, Heymach JV, Roth JA, Wu X, Zhao H. Circulating metabolite profiles to predict overall survival in advanced non- small cell lung cancer patients receiving first-line chemotherapy. Lung Cancer. 2017 Dec;114:70-78. doi: 10.1016/j.lungcan.2017.10.018. Epub 2017 Nov 2. PMID: 29173770; PMCID: PMC5715727.
