Lazabemide Hydrochloride | CAS#103878-83-7 | Pyridinecarboxamide

MedKoo Cat#: 150164 | Name: Lazabemide Hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lazabemide is a reversible and selective inhibitor of monoamine oxidase B (MAO-B) that was under clinical development against Parkinson's disease, Alzheimer's disease and as an aid to smoking cessation.

Chemical Structure

Lazabemide Hydrochloride

CAS#103878-83-7

Theoretical Analysis

MedKoo Cat#: 150164

Name: Lazabemide Hydrochloride

CAS#: 103878-83-7

Chemical Formula: C8H11Cl2N3O

Exact Mass: 235.0280

Molecular Weight: 236.10

Elemental Analysis: C, 40.70; H, 4.70; Cl, 30.03; N, 17.80; O, 6.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Lazabemide hydrochloride; Tempium; Lazabemide HCl; Lazabemide monohydrochloride;

IUPAC/Chemical Name

N-(2-aminoethyl)-5-chloropyridine-2-carboxamide;hydrochloride

InChi Key

JMFKTFLARGGXCC-UHFFFAOYSA-N

InChi Code

1S/C8H10ClN3O.ClH/c9-6-1-2-7(12-5-6)8(13)11-4-3-10;/h1-2,5H,3-4,10H2,(H,11,13);1H

SMILES Code

O=C(C1=NC=C(Cl)C=C1)NCCN.[H]Cl

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 236.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Cheng X, Lowin T, Honke N, Pongratz G. Components of the sympathetic nervous system as targets to modulate inflammation - rheumatoid arthritis synovial fibroblasts as neuron-like cells? J Inflamm (Lond). 2023 Mar 14;20(1):9. doi: 10.1186/s12950-023-00336-z. PMID: 36918850; PMCID: PMC10015726. 2: Henriot S, Kuhn C, Kettler R, Da Prada M. Lazabemide (Ro 19-6327), a reversible and highly sensitive MAO-B inhibitor: preclinical and clinical findings. J Neural Transm Suppl. 1994;41:321-5. doi: 10.1007/978-3-7091-9324-2_42. PMID: 7931245.