Synonym
Alphaxalone; Alfaxalone; 5alpha-Pregnan-3alpha-ol-11,20-dione; Alfaxalonum;
IUPAC/Chemical Name
(3R,5S,8S,9S,10S,13S,14S,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-11-one
InChi Key
DUHUCHOQIDJXAT-OLVMNOGESA-N
InChi Code
1S/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14+,15-,16+,17-,19+,20-,21+/m0/s1
SMILES Code
O=C1C[C@]2(C)[C@@H](C(C)=O)CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@H](O)CC[C@]4(C)[C@@]13[H]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
332.48
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Martín Bellido V, Vettorato E. Clinical review of the pharmacological and anaesthetic effects of alfaxalone in dogs. J Small Anim Pract. 2022 May;63(5):341-361. doi: 10.1111/jsap.13454. Epub 2021 Dec 10. PMID: 34893985.
2: Warne LN, Beths T, Whittem T, Carter JE, Bauquier SH. A review of the pharmacology and clinical application of alfaxalone in cats. Vet J. 2015 Feb;203(2):141-8. doi: 10.1016/j.tvjl.2014.12.011. Epub 2014 Dec 16. PMID: 25582797.
3: Erickson RL, Blevins CE, Souza Dyer C, Marx JO. Alfaxalone-Xylazine Anesthesia in Laboratory Mice (Mus musculus). J Am Assoc Lab Anim Sci. 2019 Jan 1;58(1):30-39. doi: 10.30802/AALAS-JAALAS-18-000010. Epub 2018 Dec 20. PMID: 30572981; PMCID: PMC6351053.
4: Goodwin WA, Pasloske K, Keates HL, Ranasinghe MG, Woldeyohannes S, Perkins N. Alfaxalone for total intravenous anaesthesia in horses. Vet Anaesth Analg. 2019 Mar;46(2):188-199. doi: 10.1016/j.vaa.2018.09.047. Epub 2018 Oct 28. PMID: 30713053.
5: Johnson AK, Trumble J, Johnson JA, Clark-Price S, Kemppainen R. Alfaxalone increases measured progesterone concentration in neutered male cats when determined by immunoreactivity. J Am Vet Med Assoc. 2023 Sep 21;261(12):1-4. doi: 10.2460/javma.23.07.0406. PMID: 37734719.
6: West SE, Lee JC, Johns TN, Nunamaker EA. Intraperitoneal Alfaxalone and Alfaxalone-Dexmedetomidine Anesthesia in Sprague-Dawley Rats (Rattus norvegicus). J Am Assoc Lab Anim Sci. 2020 Sep 1;59(5):531-538. doi: 10.30802/AALAS-JAALAS-19-000161. Epub 2020 Aug 5. PMID: 32758333; PMCID: PMC7479773.
7: Yoshizawa K, Ukai S, Kuroda J, Yamauchi T, Yamada D, Saitoh A, Iriyama S, Nishino S, Miyazaki S. Alfaxalone improved in acute stress-induced tactile hypersensitivity and anxiety-like behavior in mice. Neuropsychopharmacol Rep. 2022 Jun;42(2):213-217. doi: 10.1002/npr2.12233. Epub 2022 Feb 4. PMID: 35118831; PMCID: PMC9216362.
8: Serrao JM, Goodchild CS. Alfaxalone anaesthesia increases brain derived neurotrophic factor levels and preserves postoperative cognition by activating pregnane-X receptors: an in vitro study and a double blind randomised controlled trial. BMC Anesthesiol. 2022 Dec 24;22(1):401. doi: 10.1186/s12871-022-01940-x. PMID: 36564723; PMCID: PMC9789577.
9: Greunz EM, Limón D, Bertelsen MF. Alfaxalone Sedation in Black-cheeked Lovebirds (Agapornis nigrigenis) for Non-invasive Procedures. J Avian Med Surg. 2021 Jul;35(2):161-166. doi: 10.1647/19-00015. PMID: 34256546.
