Stilbostat | CAS#15470-58-3 | hormone-cytostatic drug

MedKoo Cat#: 145426 | Name: Stilbostat

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Stilbostat is a hormone-cytostatic drug. STILBOSTAT does not influence the estradiol binding capacity of rat uterus tissue and tissues of human and experimentally induced mammary tumors.

Chemical Structure

Stilbostat

CAS#15470-58-3

Theoretical Analysis

MedKoo Cat#: 145426

Name: Stilbostat

CAS#: 15470-58-3

Chemical Formula: C28H34Cl4N2O4

Exact Mass: 602.1273

Molecular Weight: 604.39

Elemental Analysis: C, 55.64; H, 5.67; Cl, 23.46; N, 4.64; O, 10.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Stilbostat;

IUPAC/Chemical Name

(E)-hex-3-ene-3,4-diylbis(4,1-phenylene) bis(bis(2-chloroethyl)carbamate)

InChi Key

BOIZOYRDXIYMCY-OCEACIFDSA-N

InChi Code

1S/C28H34Cl4N2O4/c1-3-25(21-5-9-23(10-6-21)37-27(35)33(17-13-29)18-14-30)26(4-2)22-7-11-24(12-8-22)38-28(36)34(19-15-31)20-16-32/h5-12H,3-4,13-20H2,1-2H3/b26-25+

SMILES Code

CC\C(=C(\CC)C1=CC=C(OC(=O)N(CCCl)CCCl)C=C1)C2=CC=C(OC(=O)N(CCCl)CCCl)C=C2

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 604.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zimel H, Dimitriu L, Mîndroiu T, Mateescu GH, Gălăţeanu I, Marinescu M, Arsene J. Scanning of the prostate with Stilbostat-131I. Endocrinologie. 1977 Apr-Jun;15(2):127-31. PMID: 559345. 2: Görlich M, Heise E. Contribution to the mechanism of Stilbostat action. Neoplasma. 1976;23(4):363-9. PMID: 1004653. 3: Zimel H, Bocancea D. Treatment of prostatic carcinoma with Stilbostat. Neoplasma. 1974;21(1):101-8. PMID: 4596007. 4: Zimel A, Taşcă C, Ghinea E, Stefäneanu L. Influence of the "Corynebacterium parvum" vaccine and stilbostat on intratesticular development of Walker 256 carcinosarcoma in hyper- or hypothyroidized Wistar rats. Endocrinologie. 1981 Apr-Jun;19(2):105-10. PMID: 7256164. 5: Zimel H, Broder D, Zimel A. Efectele terapeutice ale preparatului "stilbostat" în cancerul mamar în stadii avansate după menopauză [Therapeutic effects of the preparation "Stilbostat" in advanced stages of breast cancer after the menopause]. Stud Cercet Endocrinol. 1973;24(3):211-9. Romanian. PMID: 4703920. 6: Zimel H, Zimel A, Petrescu R, Ghinea E, Tasca C. Influence of stress and of endocrine imbalance on the experimental metastasis. Neoplasma. 1977;24:151-9. PMID: 865645. 7: Zimel H, Mogos I, Maltezeanu G. Estimation of StilbostatR treatment efficiency in breast cancer by thermography. Neoplasma. 1977;24(5):553-7. PMID: 927612.