IUPAC/Chemical Name
1-(10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-methylpiperazine
InChi Key
MYFNXITXHNLSJY-UHFFFAOYSA-N
InChi Code
1S/C19H22N2S/c1-20-10-12-21(13-11-20)17-14-15-6-2-4-8-18(15)22-19-9-5-3-7-16(17)19/h2-9,17H,10-14H2,1H3
SMILES Code
CN1CCN(CC1)C2CC3=CC=CC=C3SC4=CC=CC=C24
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
310.46
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Queisnerová M, Svátek E, Macek K, Metysová J. Príspĕvek k poznání biotransformace perathiepinu in vivo [Contribution to the biotransformation of perathiepin in vivo]. Cesk Farm. 1968 Jun;17(5):248-51. Czech. PMID: 5680647.
2: Dlabac A, Kazdová E. Long-acting neuroleptics of perathiepin group: VUFB-9977 (oxyprothepin decanoate). Act Nerv Super (Praha). 1974 Aug;16(3):166-7. PMID: 4417411.
3: Jílek L, Trojan S. The effect of perathiepin and octoclothepin on cerebral ischaemia in rats during ontogeny. Act Nerv Super (Praha). 1967 Nov;9(4):427-8. PMID: 5612968.
4: Protiva M, Metysová J. Relations between structure and central depressant activity in the series of perathiepin analogs. Act Nerv Super (Praha). 1967 Nov;9(4):422-4. PMID: 5612965.
5: Nĕmec J. Cardiotoxicity of tricyclic antipsychotic drugs perathiepin and oxyprothepin in rats. Act Nerv Super (Praha). 1972;14(2):124-5. PMID: 5040158.
6: Jílek JO, Sindelár K, Protiva M. Esters of alcohols of the perathiepin series with prolonged neuroleptic activity. Act Nerv Super (Praha). 1972;14(2):125-6. PMID: 5040159.
7: Queisnerová M, Svátek E, Macek K, Metysová J. Contribution to biotransformation of thiepin derivatives (octoclothepin and perathiepin) in vivo. Act Nerv Super (Praha). 1968 Oct 3;10(3):335-6. PMID: 5702556.
8: Sindelár K, Metysová J, Protiva M. A new group of highly potent neuroleptic drugs in the series of 10-piperazi nodibenzo (b,f) thiepins: 8-Acyl derivatives of perathiepin (chemistry and pharmacology). Act Nerv Super (Praha). 1973 May;15(2):97-8. PMID: 4778603.
9: Domino EF, Gahagan S, Adinoff B, Kovacic B. Effects of various neuroleptics on rabbit hyperthermia induced by N, N-Dimethyltryptamine (DMT) and d-amphetamine. Arch Int Pharmacodyn Ther. 1977 Mar;226(1):30-47. PMID: 17371.
10: Náhunek K, Svestka J, Rodová A, Misurec J. Therapeutischer Versuch mit Perathiepin bei Psychosen, Beeinflussung der photomyoklonischen Schwelle [Therapeutic trial with perathiepine in psychoses and its effect on the photomyoclonic threshold]. Act Nerv Super (Praha). 1967 Nov;9(4):430-2. German. PMID: 5612970.
