Synonym
Pheophorbide a (mixture of diastereomers); Pheophorbide a;
InChi Key
OXZGBKMYWHOOCY-LRFBBPTGSA-N
InChi Code
InChI=1S/C35H36N4O5/c1-8-19-15(3)22-12-24-17(5)21(10-11-28(40)41)32(38-24)30-31(35(43)44-7)34(42)29-18(6)25(39-33(29)30)14-27-20(9-2)16(4)23(37-27)13-26(19)36-22/h8,12-14,17,21,31,37-38H,1,9-11H2,2-7H3,(H,40,41)/b24-12-,25-14-,26-13-,32-30-
SMILES Code
CC1=C2C3=N/C1=C\C4=C(C(C)=C(/C=C(C(C=C)=C5C)\N=C5/C=C(C(C/6CCC(O)=O)C)\NC6=C3\C(C(OC)=O)C2=O)N4)CC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
592.70
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1.) Kay, Andreas; Graetzel, Michael, Artificial photosynthesis. Photosensitization of titania solar cells with chlorophyll derivatives and related natural porphyrins, Journal of Physical Chemistry (1993), 97(23), 6272-7.
2.) Robey, Robert W.; Steadman, Kenneth; Polgar, Orsolya; Morisaki, Kuniaki; Blayney, Margaret; Mistry, Prakash; Bates, Susan E., 9. Pheophorbide a Is a Specific Probe for ABCG2 Function and Inhibition, Cancer Research (2004), 64(4), 1242-1246. DOI:10.1158/0008-5472.CAN-03-3298.
3.) Schelbert, Silvia; Aubry, Sylvain; Burla, Bo; Agne, Birgit; Kessler, Felix; Krupinska, Karin; Hortensteiner, Stefan, Pheophytin pheophorbide hydrolase (pheophytinase) is involved in chlorophyll breakdown during leaf senescence in Arabidopsis, Plant Cell (2009), 21(3), 767-785. DOI:10.1105/tpc.108.064089.
4.) Pruzinska, Adriana; Tanner, Gaby; Anders, Iwona; Roca, Maria; Hoertensteiner, Stefan, Chlorophyll breakdown: pheophorbinde a oxygenase is a Rieske-type iron-sulfur protein, encoded by the accelerated cell death 1 gene, Proceedings of the National Academy of Sciences of the United States of America (2003), 100(25), 15259-15264. DOI:10.1073/pnas.2036571100
