TL-310 is a new taxane analog that demonstrates potent antitumor activity in a variety of human cancer cell lines and in human tumor xenografts. The mechanism of action of TL-310 includes microtubule polymerization, resulting in a block in the G2/M phase of the cell cycle and programmed cell death (apoptosis). In the 786-0 human renal carcinoma model, oral TL-310 (80 mg/kg) was equally efficacious as IV administered paclitaxel or docetaxel. Orally administered TL-310 consistently maintained excellent antitumor efficacy which was well below its maximum tolerated dose in mice.
MedKoo Cat#: 202960
Name: TL-310
CAS#: 352697-38-2
Chemical Formula: C45H55NO16
Exact Mass: 865.3521
Molecular Weight: 865.91
Elemental Analysis: C, 62.42; H, 6.40; N, 1.62; O, 29.56
The following data is based on the product molecular weight 865.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
